Document 0019
 DOCN  M94A0019
 TI    Effect of glycyrrhizin in children with liver dysfunction associated
       with cytomegalovirus infection.
 DT    9412
 AU    Numazaki K; Umetsu M; Chiba S; Department of Pediatrics, School of
       Medicine, Sapporo Medical; University, Japan.
 SO    Tohoku J Exp Med. 1994 Feb;172(2):147-53. Unique Identifier : AIDSLINE
       MED/94353395
 AB    Glycyrrhizin (GL) has an inhibitory effect on several viruses including
       human immunodeficiency virus type 1 (HIV-1) and varicella-zoster virus
       (VZV). In addition, some therapeutic and prophylactic effects on chronic
       active viral hepatitis have been claimed for GL. In this study, 0.2% GL
       dissolved in saline (2 mg/ml GL), supplemented with 2% glycine and 0.1%
       cysteine (Stronger Neo-Minophagen C, SNMC) was administered
       intravenously in a dose of 50 ml/day for a period of more than one week
       to three infants with cytomegalovirus (CMV) infection who exhibited
       abnormal liver function or hepatomegaly. Liver function had become
       normal at the end of the course of SNMC. These findings suggest that GL
       might have therapeutic effects on liver dysfunction associated with CMV
       infections.
 DE    Antibodies, Viral/ANALYSIS  Antiviral Agents/ADMINISTRATION &
       DOSAGE/*THERAPEUTIC USE  Case Report
       Cytomegalovirus/IMMUNOLOGY/ISOLATION & PURIF  Cytomegalovirus
       Infections/COMPLICATIONS/*DRUG THERAPY  Female  Glycyrrhetinic
       Acid/*ANALOGS & DERIVATIVES/ADMINISTRATION &  DOSAGE/THERAPEUTIC USE
       Human  IgG/ANALYSIS  IgM/ANALYSIS  Infant  Infusions, Intravenous  Liver
       Diseases/*DRUG THERAPY/MICROBIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).