Document 0029
 DOCN  M94A0029
 TI    Prophylactic vaccines, risk behavior change, and the probability of
       eradicating HIV in San Francisco.
 DT    9412
 AU    Blower SM; McLean AR; Epidemiology Department, School of Public Health,
       University of; California at Berkeley 94720.
 SO    Science. 1994 Sep 2;265(5177):1451-4. Unique Identifier : AIDSLINE
       MED/94353245
 AB    Theory is linked with data to assess the probability of eradicating
       human immunodeficiency virus (HIV) in San Francisco through the use of
       prophylactic vaccines. The necessary vaccine efficacy levels and
       population coverage levels for eradication are quantified. The likely
       impact of risk behavior changes on vaccination campaigns is assessed.
       The results show it is unlikely that vaccines will be able to eradicate
       HIV in San Francisco unless they are combined with considerable
       reductions in risk behaviors. Furthermore, if risk behavior increases as
       the result of a vaccination campaign, then vaccination could result in a
       perverse outcome by increasing the severity of the epidemic.
 DE    Adult  *AIDS Vaccines  Disease Outbreaks/PREVENTION & CONTROL
       *Homosexuality  Human  HIV Infections/EPIDEMIOLOGY/*PREVENTION & CONTROL
       Immunization Programs  Male  Probability  *Risk-Taking  San
       Francisco/EPIDEMIOLOGY  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).