Document 0035
 DOCN  M94A0035
 TI    Inhibitory effect of some triterpenoid saponins on glucose transport in
       tumor cells and its application to in vitro cytotoxic and antiviral
       activities.
 DT    9412
 AU    Hasegawa H; Matsumiya S; Uchiyama M; Kurokawa T; Inouye Y; Kasai R;
       Ishibashi S; Yamasaki K; Itto Institute of Life Science Research, Happy
       World Inc., Tokyo,; Japan.
 SO    Planta Med. 1994 Jun;60(3):240-3. Unique Identifier : AIDSLINE
       MED/94353029
 AB    The effects of some triterpenoid saponins on glucose transport in
       Ehrlich ascites tumor (EAT) cells were examined by measuring
       2-deoxy-D-glucose (2-DG) uptake. The correlation of the effects with
       those on the growth of a human T-cell line (MT-4) and the replication of
       human immunodeficiency virus in MT-4 cells was also studied.
       Chikusetsusaponin Ia isolated from rhizomes of Panax japonicus C. A.
       Meyer (Araliaceae) inhibited the 2-DG uptake (IC50 = 76.3 microM) in a
       competitive fashion with respect to 2-DG (Ki = 0.32 mM) and the growth
       of MT-4 cells with CC50 of 84.4 microM, whereas it did not show any
       significant anti-HIV-1 activity. In contrast, zingibroside R1 isolated
       from rhizomes of Panax zingiberensis Wu et Feng (Araliaceae) showed some
       anti-HIV-1 activity, which was found to be superior to that of
       glycyrrhizin, as well as the inhibitory effects on the 2-DG uptake by
       EAT cells (IC50 = 91.3 microM) and the growth of MT-4 cells (CC50 = 46.2
       microM).
 DE    Animal  Antineoplastic Agents/*PHARMACOLOGY  Antiviral
       Agents/*PHARMACOLOGY  Biological Transport/DRUG EFFECTS  Cell Line
       Glucose/*PHARMACOKINETICS  Male  Mice  Saponins/*PHARMACOLOGY
       Triterpenes/*PHARMACOLOGY  Tumor Cells, Cultured  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).