Document 0036
 DOCN  M94A0036
 TI    Synthesis of some 6-methylidene-9-purine acyclic nucleosides with
       expected anti-HIV activity.
 DT    9412
 AU    el-Kousy S; Chemistry Department, Faculty of Science, Menoufiya
       University,; Shebin El-Kom, Egypt.
 SO    Pharmazie. 1994 Jul;49(7):480-2. Unique Identifier : AIDSLINE
       MED/94352991
 AB    Reaction of 6-chloro,9-(2-acetoxyethoxymethyl)purine 1 with ethyl
       cynoacetat, malononitrile and diethyl malonate in presence of NaH and
       DMF yielded the corresponding 6-methylidene derivatives 2a-c, which were
       deprotected by treatment with methanolic Ammonia to yield 3a-c. During
       the reaction of 1 with cyanoacetamide deacetylation took place
       spontaneously resulting in the deprotected acyclic nucleoside 4.
       Treatment of 2a with methyliodide in presence of NaH and DMF yielded the
       N-methyl derivative 5. NMR and mass spectra of the synthesized compounds
       are discussed.
 DE    Antiviral Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY  HIV/*DRUG EFFECTS
       Nuclear Magnetic Resonance  Nucleosides/*CHEMICAL SYNTHESIS/PHARMACOLOGY
       JOURNAL ARTICLE

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