Document 0068
 DOCN  M94A0068
 TI    Effect of enteral tube feeding on growth of children with symptomatic
       human immunodeficiency virus infection.
 DT    9412
 AU    Henderson RA; Saavedra JM; Perman JA; Hutton N; Livingston RA; Yolken
       RH; Department of Pediatrics, Johns Hopkins University, School of;
       Medicine, Baltimore, Maryland.
 SO    J Pediatr Gastroenterol Nutr. 1994 May;18(4):429-34. Unique Identifier :
       AIDSLINE MED/94351460
 AB    Malnutrition and growth failure are frequent clinical consequences of
       human immunodeficiency virus (HIV) infection in children. Tube feeding
       is a means by which to increase the enteral intake of nutrients. We
       examined the effect of tube feeding in 18 children, median age 6 months
       (range, 3-159). Tube feedings were initiated due to growth failure in
       all, which was also associated with dysfunctional swallowing or
       aspiration in seven children and gastroesophageal reflux in two. Tube
       feedings were infused via nasogastric tube (n = 4) or gastrostomy tube
       (n = 14) and were continued for a median of 8.5 months (range, 2-24).
       Stoma complications developed in three children with gastrostomy tubes;
       these were the only tube-related side effect. Tube feedings were
       discontinued due to noncompliance (n = 3), gastrostomy leakage (n = 2),
       intolerance (n = 2), and death (n = 3). Anthropometric changes were
       evaluated comparing mean standard deviation scores (Z) before and after
       tube feeding. Tube feeding resulted in significantly increased weight
       for age (Z, -2.13 +/- 0.7 vs. -1.46 +/- 1.4; p = 0.04), weight for
       height (Z, -1.07 +/- 1.0 vs. -0.13 +/- 1.0; p = 0.004), and arm fat area
       (Z, -1.75 +/- 1.3 vs. -0.62 +/- 1.2; p = 0.01). However, tube feeding
       did not result in significant changes in height for age (Z, -1.93 +/-
       0.8 vs. -1.74 +/- 1.6) or arm muscle area (Z, -1.24 +/- 0.9 vs. -0.57
       +/- 1.2). Tube feedings effectively increased the weight of HIV-infected
       children in this study, but they were not sufficient to correct linear
       growth deficits.
 DE    Adolescence  Anthropometry  Body Height  Child  Child, Preschool
       *Enteral Nutrition  Female  *Growth  Human  HIV
       Infections/COMPLICATIONS/*THERAPY  Infant  Male  Nutrition
       Disorders/COMPLICATIONS/THERAPY  Support, U.S. Gov't, P.H.S.  Weight
       Gain  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).