Document 0074
 DOCN  M94A0074
 TI    Use of suicide genes in gene therapy.
 DT    9412
 AU    Tiberghien P; Histocompatibility and Immuno-Molecular Therapeutics
       Laboratory,; Centre Regionale de Transfusion Sanguine, Besancon, France.
 SO    J Leukoc Biol. 1994 Aug;56(2):203-9. Unique Identifier : AIDSLINE
       MED/94351257
 AB    Gene therapy encompasses a broad range of treatment modalities that may
       eventually be applied to a variety of genetic as well as acquired
       diseases. In addition to compensating for a defective gene--and
       enhancing a cellular function--gene transfer can allow for a conditional
       negative selection of target cells. Indeed, the transfer of a gene
       encoding a susceptibility factor can make a cell specifically sensitive
       to a drug. After genomic integration, such as potentially destructive
       gene is endogenously expressed and has therefore been coined a suicide
       gene. This review describes current experimental approaches and
       prospects for using suicide genes for the treatment of human diseases.
 DE    Acquired Immunodeficiency Syndrome/THERAPY  Animal  Gene
       Therapy/*METHODS  Gene Transfer  Human  Neoplasms/THERAPY  Neoplasms,
       Experimental/THERAPY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).