Document 0075
 DOCN  M94A0075
 TI    Temporal profile of hepatitis C virus antibody and genome in infants
       born to mothers infected with hepatitis C virus but without human
       immunodeficiency virus coinfection.
 DT    9412
 AU    Ni YH; Lin HH; Chen PJ; Hsu HY; Chen DS; Chang MH; Department of
       Pediatrics, College of Medicine, National Taiwan; University, Taipei,
       R.O.C.
 SO    J Hepatol. 1994 May;20(5):641-5. Unique Identifier : AIDSLINE
       MED/94351182
 AB    To investigate mother-to-infant transmission of hepatitis C virus,
       serial follow-up of anti-HCV and hepatitis C virus RNA was undertaken in
       11 infants born to hepatitis C virus-infected mothers who had been
       screened from 11,688 pregnant women. None of the hepatitis C
       virus-infected mothers was infected by human immunodeficiency virus.
       Anti-HCV was checked by the second-generation enzyme immunoassay kit,
       and hepatitis C virus RNA was examined by reverse transcriptase-nested
       polymerase chain reaction. Hepatitis C virus RNA was found in more than
       two serum samples in two of these 11 infants; those two infants were
       regarded as hepatitis C virus-infected. One of the two had hepatitis C
       virus RNA at the age of 1, 3, and 6 months, but not later. The course of
       hepatitis C virus RNA and anti-HCV in this baby may reflect fluctuating
       viral replication in chronic infectious disease or viral clearance in
       acute infection. The other infant had hepatitis C virus RNA detectable
       at the age of 3 months and at 15, 18 and 24 months. In the other nine
       non-hepatitis C virus-infected infants, maternally acquired anti-HCV
       gradually disappeared by the age of 6 months. The liver function profile
       fell to the normal range in all the infants, including the two hepatitis
       C virus-infected infants. This may indicate the subclinical nature of
       hepatitis C virus infection in infancy. Seven fathers and four siblings
       of these 11 infants were checked for anti-HCV and liver function tests;
       none had evidence of hepatitis C virus infection.(ABSTRACT TRUNCATED AT
       250 WORDS)
 DE    Base Sequence  Female  *Genome, Viral  Hepatitis Antibodies/*ANALYSIS
       Hepatitis C/COMPLICATIONS/*IMMUNOLOGY  Hepatitis C
       Viruses/*GENETICS/*IMMUNOLOGY  Human  HIV Infections/COMPLICATIONS
       Infant, Newborn  Maternal-Fetal Exchange  Molecular Probes/GENETICS
       Molecular Sequence Data  Polymerase Chain Reaction  Pregnancy  Pregnancy
       Complications, Infectious/*IMMUNOLOGY  RNA, Viral/ANALYSIS  Support,
       Non-U.S. Gov't  Time Factors  Transcription, Genetic  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).