Document 0127
 DOCN  M94A0127
 TI    The theory of genotypic selection: predicting the direction of evolution
       as a consequence of G:U base pairing and the existence of non-pathogenic
       strains of HIV-1.
 DT    9412
 AU    Pieczenik G; Department of Biochemistry and Microbiology, Rutgers
       University,; New Brunswick, NJ 08903.
 SO    Biochem Mol Biol Int. 1994 Apr;32(5):879-87. Unique Identifier :
       AIDSLINE MED/94348438
 AB    One aspect of the Theory of Genotypic Selection states that G:U base
       pairs are selected for function and structure. RNA secondary structures
       stabilised by G:U base pairs are suggested to be involved in the
       evolution of attenuated strains of polio virus. Asymmetric mutations
       (C-->U and A-->G) and convergent evolutionary solutions are explained as
       a direct consequence of G:U base pairing. The possibility of a naturally
       occurring attenuated strain of HIV-1 is predicted.
 DE    Base Composition  Base Sequence  *Evolution  Forecasting  Genotype
       Guanine/*ANALYSIS  HIV-1/*GENETICS  Models, Genetic  Molecular Sequence
       Data  Mutation  Polioviruses/GENETICS  *Selection (Genetics)
       Structure-Activity Relationship  Uridine/*ANALYSIS  Vaccines, Attenuated
       JOURNAL ARTICLE

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