Document 0154
 DOCN  M94A0154
 TI    The kinetics of cytokine secretion and proliferation by mesenteric lymph
       node cells during the progression to murine AIDS, caused by LP-BM5
       murine leukemia virus infection.
 DT    9412
 AU    Huang DS; Wang Y; Marchalonis JJ; Watson RR; Department of Family &
       Community Medicine, University of Arizona,; Tucson 85724.
 SO    Reg Immunol. 1993 Nov-Dec;5(6):325-31. Unique Identifier : AIDSLINE
       MED/94347595
 AB    A murine acquired immunodeficiency syndrome (MAIDS) is induced in
       genetically susceptible strains of mice inoculated with LP-BM5 murine
       leukemia virus. It is characterized by progressive lymphoproliferation,
       profound immunodeficiency, and the subsequent loss of resistance to
       opportunistic pathogens, including intestinal pathogens. Cellular and/or
       humoral immunity of gut-associated lymphoid tissues may play a key role
       in the elimination of these pathogens. We have previously demonstrated
       reductions in the number of mucosal T and B cells in MAIDS. In this
       study, the cytokine production by mesenteric lymph nodes (MLN) cells and
       their proliferative response to mitogens during MAIDS were investigated.
       Alterations were observed in the kinetics of MLN cell proliferation and
       cytokine secretion by in vitro mitogen-stimulated MLN cells during the
       retrovirus infection. Cytokine production was abnormally changed, with a
       gradual decrease in interleukin-2 (IL-2) production as well as an
       increase in IL-5 and IL-6 secretion. Interferon-gamma production was
       increased during the progression to MAIDS. The dysregulated release of
       cytokines by MLN cells due to retrovirus infection could lead to immune
       dysfunction. These data indicate that dysregulated cytokine secretion by
       MLN cells may be responsible for impaired mucosal immunity in AIDS,
       explaining the dramatic increase of opportunistic intestinal pathogens
       in individuals with AIDS.
 DE    Animal  Body Weight  Cell Division  Cells, Cultured
       Cytokines/*SECRETION  DNA/BIOSYNTHESIS  Enzyme-Linked Immunosorbent
       Assay  Female  Leukemia Viruses, Murine  Lymph Nodes/*IMMUNOLOGY
       Mesentery  Mice  Mice, Inbred C57BL  Mitogens  Murine Acquired
       Immunodeficiency Syndrome/*IMMUNOLOGY  Organ Weight  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).