Document 0181
 DOCN  M94A0181
 TI    Immune complex deposition in the choroid plexus of patients with
       acquired immunodeficiency syndrome.
 DT    9412
 AU    Falangola MF; Castro-Filho BG; Petito CK; Department of Pathology,
       University of Miami School of Medicine,; FL 33136.
 SO    Ann Neurol. 1994 Sep;36(3):437-40. Unique Identifier : AIDSLINE
       MED/94361475
 AB    We identified immune complex deposits in the choroid plexus of
       approximately 75% of patients with acquired immunodeficiency syndrome
       (AIDS) who had either normal brains or human immunodeficiency virus
       encephalitis. Since circulating immune complexes are common in AIDS
       patients, and since local choroid plexus pathology usually was absent,
       their likely origin is from the bloodstream. Choroid plexus deposits of
       immune complexes have been implicated in altering the function of this
       structure or in enhancing its vulnerability to infection. Therefore,
       immune complex deposition in the choroid plexus of AIDS patients may be
       responsible for some of the common alterations in the cerebrospinal
       fluid and for the frequency of opportunistic infections in this region.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY  Adult
       Antigen-Antibody Complex/*METABOLISM  Choroid
       Plexus/*IMMUNOLOGY/PATHOLOGY  Female  Human  Male  Middle Age  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).