Document 0183
 DOCN  M94A0183
 TI    New perspectives on use of thymic factors in immune deficiency.
 DT    9412
 AU    Cunningham-Rundles S; Harbison M; Guirguis S; Valacer D; Chretien PB;
       Immunology Research Laboratory, New York Hospital, Cornell; University
       Medical College, New York 10021.
 SO    Ann N Y Acad Sci. 1994 Aug 15;730:71-83. Unique Identifier : AIDSLINE
       MED/94361420
 AB    Current knowledge on the role of thymic factors in the immune response
       is inadequate and remains relatively primitive when compared with
       present technical possibilities for assessing lymphocyte subsets or
       cytokine interaction. New studies support the potential importance of
       thymic factors as regulators of immune interactions. Indirect evidence
       supports the concept that thymic factors may work at the level of IL-2.
       The functional identity of cells responsive to thymic factors and the
       relation of observed effects to cytokine network interactions need to be
       established. The use of thymic factors in the future will depend on the
       development of criteria to identify appropriate settings in which to use
       such factors and the implementation of appropriate measures of immune
       functional response.
 DE    CD4-CD8 Ratio  Digeorge Syndrome/THERAPY  Human  Immunologic Deficiency
       Syndromes/*THERAPY  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Thymus Extracts/PHARMACOLOGY/*THERAPEUTIC USE  Thymus Gland/*IMMUNOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).