Document 0193
 DOCN  M94A0193
 TI    Effect of monoclonal antibody CD4 on expression of intercellular
       adhesion molecule 1 in renal tissues of ddY mice: a spontaneous animal
       model of IgA nephropathy.
 DT    9412
 AU    Ohmuro H; Tomino Y; Koide H; Department of Medicine, Juntendo University
       School of Medicine,; Tokyo, Japan.
 SO    Am J Nephrol. 1994;14(2):136-41. Unique Identifier : AIDSLINE
       MED/94361166
 AB    Immunofluorescence studies were performed to determine whether the
       expression of intercellular adhesion molecule 1 (ICAM-1) in ddY mice, a
       model for IgA nephropathy (Berger's disease), is influenced by treatment
       with a rat monoclonal antibody to murine CD4 molecules. The ddY mice
       were initially treated with intravenous injections, followed by weekly
       intraperitoneal injections of monoclonal antibody CD4. Using
       immunofluorescence, the mean intensity of IgA deposits in renal
       glomerular mesangial areas and capillary walls of the treated ddY mice
       was significantly lower than that in saline-treated control ddY mice of
       comparable ages. Marked expression of ICAM-1 was observed in glomerular
       capillary walls and mesangial areas in both control and treated ddY mice
       aged 40 and 70 weeks. The glomerular mesangial expansion in the treated
       ddY mice was milder than that found in the control ddY mice. No
       significant difference in glomerular cell proliferation between the
       treated and control ddY mice was observed. Although the infiltration of
       CD4+ T cells in glomeruli was slightly decreased after the treatment,
       that of CD8+ T cells and macrophages/monocytes was marked in both
       control and treated ddY mice aged 40 and 70 weeks. Thus, it appears that
       CD4+ T cells modulate the amount of IgA deposits in glomeruli, and other
       factors may be involved in the expression of ICAM-1 in glomeruli of IgA
       nephropathy in ddY mice.
 DE    Animal  Antibodies, Monoclonal  Antigens, CD4/*IMMUNOLOGY  Cell Adhesion
       Molecules/BIOSYNTHESIS/*IMMUNOLOGY  Cell Division  CD4-CD8 Ratio
       Glomerulonephritis, IGA/*IMMUNOLOGY/METABOLISM/PATHOLOGY  IgA/IMMUNOLOGY
       Kidney Glomerulus/*IMMUNOLOGY/PATHOLOGY  Lymphocyte Function-Associated
       Antigen-1/BIOSYNTHESIS/*IMMUNOLOGY  Macrophages/*IMMUNOLOGY/PATHOLOGY
       Mice  Mice, Inbred Strains  Models, Biological
       Monocytes/*IMMUNOLOGY/PATHOLOGY  Support, Non-U.S. Gov't  T4
       Lymphocytes/*IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

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