Document 0221
 DOCN  M94A0221
 TI    Comparison of vertical human immunodeficiency virus type 2 and human
       immunodeficiency virus type 1 transmission in the French prospective
       cohort. The HIV Infection in Newborns French Collaborative Study Group.
 DT    9412
 SO    Pediatr Infect Dis J. 1994 Jun;13(6):502-6. Unique Identifier : AIDSLINE
       MED/94359773
 AB    In the French prospective cohort study we compared the mother-infant
       transmission rates of human immunodeficiency virus type 1 (HIV-1) and
       human immunodeficiency virus type 2 (HIV-2). As of January 1, 1994, 86
       infants born to 68 HIV-2-seropositive mothers have been included in the
       cohort. Forty-one children had been followed up for more than 18 months
       at the time of analysis. During the same period 1758 infants born to
       1589 HIV-1-infected mothers were included; 419 mothers were of African
       origin. One thousand one hundred fifteen children had a follow-up of 18
       months or more; 260 of these were of African origin. The HIV-2
       transmission rate, based on serologic status at 18 months, was 0% (95%
       confidence interval, 0 to 11%). This was significantly lower than the
       HIV-1 transmission rate of 21% (confidence interval, 16 to 26%) in
       infants born to African mothers. The difference remained significant
       when the comparison was extended to HIV-1-positive women of French
       origin infected by the sexual route or by iv drug abuse. Most of the
       HIV-2-infected women were from West Africa; they were older and had more
       children than the HIV-1-infected women. The circulating CD4+ lymphocyte
       count was significantly higher in these women than in the HIV-1-infected
       mothers. Reported differences in the replication of the two viruses
       probably account for the lower mother-infant transmission rate of HIV-2.
 DE    Adult  Africa/ETHNOLOGY  AIDS Serodiagnosis  Cohort Studies  Comparative
       Study  Female  France/EPIDEMIOLOGY  Human  HIV
       Infections/*CONGENITAL/EPIDEMIOLOGY/IMMUNOLOGY/*TRANSMISSION
       *HIV-1/IMMUNOLOGY  *HIV-2/IMMUNOLOGY  Infant  Infant, Newborn  Pregnancy
       Pregnancy Complications, Infectious/EPIDEMIOLOGY/*IMMUNOLOGY
       Prospective Studies  Support, Non-U.S. Gov't  Virus
       Replication/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).