Document 0226
 DOCN  M94A0226
 TI    Immunologic status in patients infected with HIV with oral candidiasis
       and hairy leukoplakia.
 DT    9412
 AU    Kolokotronis A; Kioses V; Antoniades D; Mandraveli K; Doutsos I;
       Papanayotou P; School of Dentistry, Aristotle University of
       Thessaloniki,; Specific Infectious Disease Unit, Greece.
 SO    Oral Surg Oral Med Oral Pathol. 1994 Jul;78(1):41-6. Unique Identifier :
       AIDSLINE MED/94359691
 AB    Although numerous studies of oral manifestations associated with HIV
       have been reported, only a few refer to the correlation of these lesions
       with laboratory parameters. In this study we investigated the
       relationships between the two most common HIV-associated oral lesions,
       oral candidiasis and hairy leukoplakia, with the stage of the disease,
       circulating CD4+ cell counts, and the presence of anti-p24 antibodies in
       serum and stimulated whole saliva in 43 known HIV-1-infected persons.
       Although oral candidiasis and hairy leukoplakia were exclusively
       observed in subjects who were classified as Centers for Disease Control
       and Prevention group IV, only the prevalence of oral candidiasis is
       strongly associated with circulating CD4+ counts less than 200/mm3 (p <
       0.02). The prevalence of oral candidiasis and hairy leukoplakia was
       significantly related to the absence of anti-p24 antibodies in serum (p
       < 0.01 and p < 0.01, respectively), but was only statistically
       significant for hairy leukoplakia in stimulated whole saliva (p < 0.02).
       The results suggest that oral candidiasis and hairy leukoplakia in
       correlation with immunologic status as indicated by low circulating CD4+
       cell counts and the absence of anti-p24 antibodies in serum and the loss
       of secretory anti-p24 antibodies in subjects with hairy leukoplakia, may
       constitute prognostic markers for the progression of HIV-infection to
       AIDS. Our results also indicate that the absence of anti-p24 antibodies
       is not only influenced by the low levels of circulating CD4+ cells but
       probably by the presence of oral candidiasis or hairy leukoplakia as
       well.
 DE    Adolescence  Adult  AIDS-Related Opportunistic
       Infections/BLOOD/*IMMUNOLOGY  Biological Markers  Candidiasis,
       Oral/BLOOD/ETIOLOGY/*IMMUNOLOGY  Chi-Square Distribution  CD4-CD8 Ratio
       Female  Human  HIV Antibodies/BLOOD  HIV Core Protein p24/IMMUNOLOGY
       Leukoplakia, Hairy/BLOOD/ETIOLOGY/*IMMUNOLOGY  Male  Middle Age
       Prevalence  Prognosis  Saliva/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).