Document 0259
 DOCN  M94A0259
 TI    Treatment with intravenous
       (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine of
       acyclovir-resistant mucocutaneous infection with herpes simplex virus in
       a patient with AIDS.
 DT    9412
 AU    Lalezari JP; Drew WL; Glutzer E; Miner D; Safrin S; Owen WF Jr; Davidson
       JM; Fisher PE; Jaffe HS; Mount Zion Medical Center, University of
       California, San; Francisco.
 SO    J Infect Dis. 1994 Sep;170(3):570-2. Unique Identifier : AIDSLINE
       MED/94358489
 AB    (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (HPMPC) is a
       nucleotide analogue with potent in vitro and in vivo activity against a
       broad range of herpesviruses, including acyclovir-resistant herpes
       simplex virus (HSV). A patient with severe acyclovir-resistant perineal
       HSV infection received intravenous HPMPC at 5 mg/kg/week, with
       concomitant oral probenecid and prehydration, and had 95% healing after
       four infusions. The patient developed a hypersensitivity reaction to
       probenecid and discontinued HPMPC after the fourth infusion. Recurrence
       of the perineal lesions 2 weeks later prompted initiation of an oral
       desensitization program to probenecid and enabled the patient to resume
       therapy. The lesions again responded to infusions of HPMPC, but the drug
       was discontinued before complete healing because of transient
       nephrotoxicity (proteinuria, 2+; creatinine, 1.7 mg/dL). HPMPC is a
       potent antiviral agent that holds promise as a potential treatment for
       acyclovir-resistant HSV infection.
 DE    Acyclovir/*THERAPEUTIC USE  Antiviral Agents/*THERAPEUTIC USE
       AIDS-Related Opportunistic Infections/*DRUG THERAPY  Case Report
       Cytosine/*ANALOGS & DERIVATIVES/THERAPEUTIC USE  Drug Resistance,
       Microbial  Herpes Simplex/*DRUG THERAPY  Human  Male  Microbial
       Sensitivity Tests  Middle Age  Organophosphorus Compounds/*THERAPEUTIC
       USE  Simplexvirus/DRUG EFFECTS  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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