Document 0262
 DOCN  M94A0262
 TI    Development of clinical disease in cats experimentally infected with
       feline immunodeficiency virus.
 DT    9412
 AU    English RV; Nelson P; Johnson CM; Nasisse M; Tompkins WA; Tompkins MB;
       Department of Microbiology, Pathology, and Parasitology, College; of
       Veterinary Medicine, North Carolina State University, Raleigh; 27606.
 SO    J Infect Dis. 1994 Sep;170(3):543-52. Unique Identifier : AIDSLINE
       MED/94358486
 AB    Cats naturally infected with feline immunodeficiency virus (FIV) develop
       an AIDS-like syndrome whereas experimentally infected cats do not. To
       investigate the role of cofactors in the development of this disease in
       cats, 7 specific pathogen-free (SPF) and 12 random-source (RS) cats were
       infected with FIV. Over 4 years, infected cats developed similar
       phenotypic and functional immune abnormalities characterized by early
       and chronic inversion of CD4+:CD8+ cell ratios and significantly
       decreased mitogen responses compared with controls. Beginning 18-24
       months after infection, 10 RS cats developed chronic clinical disease
       typical of feline AIDS, including stomatitis and recurrent upper
       respiratory disease; 4 SPF cats also developed chronic clinical disease,
       2 with neurologic disease and 2 with B cell lymphomas. Thus, immunologic
       background is important in the type of disease that develops in cats
       infected with FIV, and FIV represents a promising animal model for
       studying the immunopathogenesis of AIDS in humans.
 DE    Animal  Antibody Formation  B-Lymphocytes/IMMUNOLOGY  Blotting, Southern
       Cats  CD4-CD8 Ratio  Feline Acquired Immunodeficiency
       Syndrome/COMPLICATIONS/  IMMUNOLOGY/*PHYSIOPATHOLOGY  Female
       Immunodeficiency Virus, Feline/ISOLATION & PURIF/*PATHOGENICITY
       Lymphocyte Subsets/*IMMUNOLOGY  *Lymphocyte Transformation  Polymerase
       Chain Reaction  Support, U.S. Gov't, P.H.S.  Time Factors  JOURNAL
       ARTICLE

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