Document 0270
 DOCN  M94A0270
 TI    Antifungal drugs on the horizon.
 DT    9412
 AU    Hay RJ; St. John's Institute of Dermatology, Guy's Hospital, London,;
       England.
 SO    J Am Acad Dermatol. 1994 Sep;31(3 Pt 2):S82-6. Unique Identifier :
       AIDSLINE MED/94358257
 AB    In the past 10 years there has been a major expansion in the development
       of antifungal drugs, but there are still weaknesses in the range and
       scope of current antifungal chemotherapy. New developments have included
       the modification of existing drug molecules to eliminate toxicity and
       improve activity, for instance, the development of the lipid
       formulations of the polyene antifungal agent amphotericin B. Three
       different amphotericin B derivatives, a unilamellar liposome (AmBisome),
       a colloidal dispersion (ABCD--Amphocil), and a lipid complex (ABLC) are
       undergoing evaluation. New triazoles with broad-spectrum antifungal
       activity, such as saperconazole, are also being assessed. The
       development of groups of drugs with novel modes of action such as cell
       wall biosynthesis inhibitors has been slower, although a number of
       molecules with activity against key enzymes, including chitin or glucan
       synthase, have been found. The morpholine antifungal amorolfine, a
       sterol biosynthesis inhibitor, has been developed for the topical
       treatment of fungal nail infections. The assessment of these drugs is a
       major challenge because it will be necessary to show that they have some
       advantage over existing compounds in efficacy, speed of action, or lack
       of toxicity.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Animal  Antifungal
       Agents/PHARMACOLOGY/*THERAPEUTIC USE  Azoles/PHARMACOLOGY/THERAPEUTIC
       USE  Cell Wall/DRUG EFFECTS/METABOLISM  Human
       Morpholines/PHARMACOLOGY/THERAPEUTIC USE  Mycoses/COMPLICATIONS/*DRUG
       THERAPY/PATHOLOGY  Polyenes/PHARMACOLOGY/THERAPEUTIC USE  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

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