Document 0283
 DOCN  M94A0283
 TI    Evaluation of temperature sensitivity of human papillomavirus type 11 by
       using the human xenograft severe combined immunodeficiency mouse model.
 DT    9412
 AU    Bonnez W; Rose RC; Borkhuis C; Da Rin C; Reichman RC; Department of
       Medicine, University of Rochester School of; Medicine and Dentistry, New
       York 14642.
 SO    J Clin Microbiol. 1994 Jun;32(6):1575-7. Unique Identifier : AIDSLINE
       MED/94358134
 AB    The temperature sensitivity of human papillomavirus type 11 was
       evaluated by using a human xenograft severe combined immunodeficiency
       mouse model. Incubation of the virus for 1 h at a temperature higher
       than 56 degrees C but lower than 72 degrees C was sufficient to inhibit
       the virally induced growth of infected human tissue. However, 100
       degrees C was necessary to completely inactivate HPV type 11 genome
       expression.
 DE    Animal  Base Sequence  Condylomata Acuminata/*MICROBIOLOGY  DNA Probes,
       HPV  Human  Male  Mice  *Mice, SCID  Molecular Sequence Data
       Papillomavirus, Human/CLASSIFICATION/*PHYSIOLOGY  Penile
       Neoplasms/*MICROBIOLOGY  Severe Combined Immunodeficiency/MICROBIOLOGY
       Skin/MICROBIOLOGY  Skin Transplantation  Subrenal Capsule Assay
       Support, U.S. Gov't, P.H.S.  *Temperature  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).