Document 0320
 DOCN  M94A0320
 TI    Effect of splenectomy on HIV-related thrombocytopenia and progression of
       HIV infection in patients with severe haemophilia.
 DT    9412
 AU    Brown SA; Majumdar G; Harrington C; Bedford M; Winter M; O'Doherty MJ;
       Savidge GF; Haemophia Reference Centre, St Thomas' Hospital, London.
 SO    Blood Coagul Fibrinolysis. 1994 Jun;5(3):393-7. Unique Identifier :
       AIDSLINE MED/94355557
 AB    Between May 1983 and September 1991 eleven patients with severe
       haemophilia underwent splenectomy for HIV-related thrombocytopenia. The
       sustained complete remission rate (platelets > 100 x 10(9)/l) was 82%
       over a mean follow-up period of 54 months. The group was compared with
       22 age-matched non-thrombocytopenic HIV seropositive haemophiliacs who
       had not undergone splenectomy. Both groups had equivalent use of factor
       concentrate and there was no significant difference between the groups
       in terms of anti-retroviral treatment. Analysis of clinical progression
       of HIV infection and CD4 positive lymphocyte (CD4+) counts, for the time
       since splenectomy, revealed no significant difference in progression of
       HIV infection in the splenectomized group compared with the control
       group. It is concluded that splenectomy is an effective treatment for
       HIV-related thrombocytopenia and has no adverse effect on the
       progression of HIV infection.
 DE    Hemophilia/*COMPLICATIONS  Human  HIV Infections/BLOOD/*COMPLICATIONS
       HIV Seropositivity  Leukocyte Count  Remission Induction  *Splenectomy
       Thrombocytopenia/COMPLICATIONS/*SURGERY  T4 Lymphocytes  JOURNAL ARTICLE

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