Document 0345
 DOCN  M94A0345
 TI    Transitory expansion of a CD3+TcR gamma/delta+CD16+ lymphocytic
       population in two patients with advanced human immunodeficiency virus
       infection and high levels of natural killer activity.
 DT    9412
 AU    Tambussi G; Albarello V; Gori A; Bisson C; Lazzarin A; Department of
       Infectious Diseases, San Raffaele Hospital, Milan,; Italy.
 SO    AIDS Res Hum Retroviruses. 1994 Jun;10(6):711-5. Unique Identifier :
       AIDSLINE MED/94355116
 AB    In the present study, we describe an expansion of CD16+ cells with a
       CD3+ TcR gamma/delta+ phenotype, in the presence of normal numbers of
       classic CD3-CD16+ natural killer (NK) cells, in two patients with human
       immunodeficiency virus (HIV) infection in late stage. The NK activity of
       the two subjects was substantially higher then that of HIV+ subjects in
       the same stage of infection. A second evaluation of one of the patients
       showed levels of NK activity consistent with the clinical stage of HIV
       infection, concomitant with a remarkable reduction in the percentage of
       double-positive CD3/TcR gamma/delta cells. The number of CD16+ cells
       also reached values comparable to those of the control group. In
       conclusion, we have identified a population of CD3+TcR gamma/delta+CD16+
       cells that have the capability to lyse an NK-sensitive target in two
       patients with unusually high levels of NK activity.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY  Adult  Antigens,
       CD3/*ANALYSIS  Case Report  Human  Immunophenotyping  *Killer Cells,
       Natural/PHYSIOLOGY  *Lymphocyte Subsets  Male  Receptors, IgG/*ANALYSIS
       JOURNAL ARTICLE

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