Document 0346
 DOCN  M94A0346
 TI    Viral leakage risk differences in latex condoms.
 DT    9412
 AU    Voeller B; Nelson J; Day C; Sequoia Associates and the Mariposa
       Foundation, Topanga,; California 90290.
 SO    AIDS Res Hum Retroviruses. 1994 Jun;10(6):701-10. Unique Identifier :
       AIDSLINE MED/94355115
 AB    Through use of a new bacteriophage assay capable of detecting a single
       viral plaque-forming unit (PFU), viral leakage through multiple
       replicates of several types of latex condoms has been evaluated. Stocks
       were used that had been preserved from a previous large study in which
       viral leakage had been assessed preliminarily in several brands. In the
       present research, much larger numbers of replicates--on the order of
       magnitude of 100 condoms per brand--were used. Leakage was demonstrated
       in single production lots of each of seven brands of condoms. With one
       notable exception, percent leakage ranged from 0.9 to 22.8%; 100% of the
       specimens of one profoundly flawed brand leaked. All test condoms were
       subjected to conditions intended to model these prevailing during
       coitus. Because the condoms used in this study were aged, current stocks
       of two widely sold brands were tested for comparison. Of these, 11.8% of
       one brand leaked, 25.7% of the other. The relevance of the results,
       which gave a high, albeit physiologically appropriate, challenge to the
       test brands, is discussed--so too is the significance to condom users of
       results deriving from a leakage assay of exquisitely high sensitivity.
 DE    Bacteriophage phi X 174/GROWTH & DEVELOPMENT  Comparative Study
       Condoms/*STANDARDS  Hepatitis A/*PREVENTION & CONTROL/TRANSMISSION
       Human  HIV Infections/*PREVENTION & CONTROL/TRANSMISSION  Materials
       Testing  Risk  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).