Document 0903
 DOCN  M94A0903
 TI    Long-term symptomless HIV positive blood transfusion recipients.
 DT    9412
 AU    Learmont J; Sullivan J; Gerrard J; Red Cross Blood Transfusion Service,
       NSW, Australia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):254 (abstract no. PC0378). Unique
       Identifier : AIDSLINE ICA10/94371672
 AB    OBJECTIVES: To establish if shared HLA antigens could have influenced
       the long-term survival of the Sydney cohort and to further examine the
       recipient with Systemic Lupus Erythematosus (SLE) who died from
       Pneumocystis carinii pneumonia (PCP) to establish if the PCP was due to
       immunosuppressive therapy and not due to AIDS. METHODS: 1. To tissue
       type the cohort for HLA Class 1 and 11 alleles. 2. To compare the
       clinical history of the SLE recipient with HIV negative
       immunocompromised adults who developed PCP. RESULTS: The group shared no
       common HLA alleles or haplotypes. The clinical history of the recipient
       closely resembled that of 27 HIV-negative patients with PCP. The
       immunosuppressive regimens used in these patients were very similar to
       that administered to the recipient. CONCLUSION: 1. Tissue typing of the
       cohort clearly demonstrated that sharing of HLA antigens did not
       influence the long-term survival of the group. 2. We believe the SLE
       recipient did not die from AIDS and her PCP was a direct result of her
       immunosuppressive therapy.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  Adult  Blood
       Transfusion/*ADVERSE EFFECTS  Cause of Death  Female  Human  HIV
       Seropositivity/*COMPLICATIONS/TRANSMISSION  Immunosuppressive
       Agents/*ADVERSE EFFECTS  Lupus Erythematosus,
       Systemic/*COMPLICATIONS/DRUG THERAPY  Pneumonia, Pneumocystis
       carinii/*ETIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).