Document 1126
 DOCN  M94A1126
 TI    Early antiretroviral treatment and survival after AIDS diagnosis in a
       cohort of homosexual men.
 DT    9412
 AU    Bindels PJ; Krol A; Keet IP; Van den Hoek JA; Coutinho RA; Municipal
       Health Service Amsterdam, The Netherlands.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):203 (abstract no. PB0827). Unique
       Identifier : AIDSLINE ICA10/94371449
 AB    OBJECTIVE: to determine whether survival after AIDS diagnosis is
       influenced by the use of early treatment with antiretroviral therapy in
       the year before AIDS diagnosis. METHODS: Of 160 participants of a cohort
       study among homosexual men in Amsterdam who developed AIDS between Jan
       1985-Dec 1992 the association between survival and the following
       variables was analyzed: use of antiretroviral therapy for at least 6
       months in the year before AIDS diagnosis (n = 46), the use of PCP
       prophylaxis until AIDS diagnosis, CD4 cell count and age at diagnosis,
       year of diagnosis, presenting AIDS diagnosis and viral phenotype (SI vs
       NSI). Kaplan Meier curves were used to estimate the survival
       probability. Cox proportional hazard models to determine independent
       predictors for surviving at least one year after AIDS diagnosis and
       independent predictors for surviving from one year after AIDS diagnosis
       onwards. RESULTS: Of the 160 participants with AIDS 111 had died at the
       end of the study period. The overall 1-, 2- and 3-year survival
       probabilities were 60% (52%-68%), 37% (29%-45%) and 20% (13%-28%) resp.
       The median survival time was 18 months. Predictors for surviving at
       least one year after AIDS diagnosis were: age > or = 40 years at
       diagnosis (RR = 1.43), being diagnosed with AIDS after 1988 (RR = 0.42)
       and CD4 cell count > 110/mm3 at diagnosis (RR = 0.54). Survival after
       the first year of AIDS diagnosis was shortened when the presenting AIDS
       diagnosis was an opportunistic infection and when antiretroviral
       treatment was used before AIDS diagnosis (RR = 2.66) CONCLUSION: Until
       the first year after AIDS diagnosis survival is predominantly predicted
       by the CD4-cell count at diagnosis. From the first year after AIDS
       diagnosis onwards the use of pre-AIDS antiretroviral therapy and the
       presenting diagnosis predict survival.
 DE    Acquired Immunodeficiency Syndrome/*DRUG THERAPY/IMMUNOLOGY/  MORTALITY
       Antiviral Agents/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Cohort
       Studies  *Homosexuality  Human  Leukocyte Count  Male  Survival Rate  T4
       Lymphocytes  MEETING ABSTRACT

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