Document 1137
 DOCN  M94A1137
 TI    Renal tissue levels of MHC protein and interferon in HIV nephropathy.
 DT    9412
 AU    Kimmel PL; Bodi I; Abraham AA; Phillips TM; George Washington Univ Med
       Ctr., Wash., DC.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):200 (abstract no. PB0815). Unique
       Identifier : AIDSLINE ICA10/94371438
 AB    Previously we found HIV proviral DNA in renal tissue of HIV+ patients
       with and without nephropathy, and increased tissue cytokines (TGF-beta,
       MCP-1, IL-8 and RANTES) in patients with HIV focal glomerulosclerosis
       (FGS), compared to patients with idiopathic FGS. Interferon (INF)
       therapy has been associated with reversible nephropathy. Renal major
       histocompatibility complex (MHC) protein expression is increased in FGS,
       and allows antigen presentation. We studied HIV+ and uninfected (-)
       patients with and without glomerulonephritis (GN) or FGS. Renal MHC and
       IFN were isolated by HPCE, and quantified by chemiluminescent
       antibodies. Mean tissue levels of renal interstitial non-polymorphic MHC
       Class II protein, INF alpha, and INF delta receptor were higher in
       patients with HIVFGS, compared to all other groups; there were no other
       group differences. TABULAR DATA, SEE ABSTRACT VOLUME. These data
       demonstrate MHC Class II proteins and INFs are associated with HIV FGS.
       Antigen presentation may be crucial to the pathogenesis of HIV
       nephropathy.
 DE    AIDS-Associated Nephropathy/*METABOLISM  Glomerulonephritis/METABOLISM
       Glomerulosclerosis, Focal/METABOLISM  Histocompatibility Antigens Class
       II/*METABOLISM  Human  Interferons/*METABOLISM  Kidney/*METABOLISM
       MEETING ABSTRACT

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       protected by Copyright Law (Title 17, U.S.Code).