Document 1148
 DOCN  M94A1148
 TI    Thyroid functional reserve evaluation in AIDS.
 DT    9412
 AU    Lima MB; Pires ML; Silva MA; Ribero JE; Alessandro FA; Dimetz T; Povoa
       LC; University of Rio de Janeiro, Brasil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):198 (abstract no. PB0807). Unique
       Identifier : AIDSLINE ICA10/94371427
 AB    OBJECTIVE: Evaluate the thyroid function reserve in the bearers of HIV,
       in different stages of the infection. METHODS: 34 patients (pt), between
       20-50 years old, without previous history of thyroid disease or use of
       drugs that could interfere in the thyroid function, were classified in 4
       clinical groups (G): 8 pt with anti-HIV tests (-) (GI-control) and 26 pt
       with anti-HIV tests (+), among these pt 9 pt non symtomatics (GII), 9 pt
       with ARC(GIII) and 8 pt with AIDS (GIV). The evaluation was made by the
       seric hormonal dosages of TSH, T3, T4, free T3, free T4, in basal state
       and 30-60-120 minutes after intravenous injection of 200mcg of
       TRH(Thyrotropin Releasing Hormone). The used statistic methods were
       ANOVA and Newman-Kews. RESULTS: High levels of basal TSH were found in 2
       pt from the GIII (22, 2%) and hyperresponse to TRH were observed 30
       minutes after stimulation in 4 pt from the GIII (44.4%) and 2 pt from
       the GIV (25%). Seric measures of the T3, T4, free T3, free T4 in basal
       and after stimulation were in the hormonal range. CONCLUSIONS: There are
       difference statistically significative (p 0.005) among valves of TSH in
       30 and 60 minutes after stimulation between the groups. Exagerated
       response of TSH to TRH in the groups III and IV may reflect subclinical
       hypothyroidim as a consequence of the subjacent infection by HIV in the
       thyroid.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*PHYSIOPATHOLOGY  Adult
       AIDS-Related Complex/PHYSIOPATHOLOGY  Human  HIV
       Seropositivity/PHYSIOPATHOLOGY  Middle Age  Thyroid Function Tests
       Thyroid Gland/*PHYSIOPATHOLOGY  Thyroid Hormones/BLOOD
       Thyrotropin/BLOOD  MEETING ABSTRACT

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