Document 1158
 DOCN  M94A1158
 TI    Diabetes insipidus in AIDS.
 DT    9412
 AU    Harris P; Curry R; AIDS Clinical Research Center of Washington, DC
       20009.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(2):196 (abstract no. PB0797). Unique
       Identifier : AIDSLINE ICA10/94371417
 AB    OBJECTIVE: Ten of 200 patients have complained over the last year of
       polyuria, polydipsia and nocturia. We were interested in whether
       diabetes insipidus (DI) may be directly associated with this infection.
       METHODS: We measured urine and serum osmolalities, serum antidiuretic
       hormone (ADH), serum sodium, BUN, glucose and potassium levels;
       calculated serum osmolalities; evaluated CD4 and CD8 counts, Beta-2
       microglobulin and HIV P-24 antigen levels; assessed recent brain scans;
       reviewed clinical pictures and noted current medications. RESULTS: ADH
       levels were less than 1 pg/ml, serum osmolalities 295-312 mos/kg H2O,
       CD4 levels 3-564/cmm, CD8 levels 86-1186/cmm, Beta-2 microglobulin
       levels 3.5-5.6 mg/l. Five had reactive HIV P-24 antigens. Seven had
       essentially normal MRI's (3 not done). Medication and secondary
       infection did not account for DI. DISCUSSION AND CONCLUSIONS: That 5% of
       our patients have primary central diabetes insipidus suggests DI may be
       an underestimated complication of HIV infection.
 DE    beta 2-Microglobulin/ANALYSIS  Acquired Immunodeficiency
       Syndrome/BLOOD/*COMPLICATIONS/  IMMUNOLOGY  Blood Urea Nitrogen  CD4-CD8
       Ratio  Diabetes Insipidus/BLOOD/*COMPLICATIONS  Human  Osmolar
       Concentration  Vasopressins/BLOOD  MEETING ABSTRACT

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