Document 2411
 DOCN  M94A2411
 TI    A score with immunological, virological and clinical features to
       estimate HIV progression in perinatal HIV-infection.
 DT    9412
 AU    Mentzer D; Funk M; Sehrt P; Cinatl J; Pfeiffer A; Steiner JJ; Dorr HW;
       Kreuz W; Centre of Pediatrics, University Frankfurt am Main, Germany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):310 (abstract no. PC0169). Unique
       Identifier : AIDSLINE ICA10/94370164
 AB    OBJECTIVE: Progression of HIV-infection is difficult to predict by
       laboratory data. The following score was used to characterize
       progression of HIV- disease in perinatally infected children: TABULAR
       DATA, SEE ABSTRACT VOLUME. Flow cytometric evaluation: CD4(+) cell
       count, assay of syncytium forming units (SFU) in lymphocyte culture,
       quantitative p-24 antigen-ELISA in serum, lean body mass (LBM) (*sex-
       and age- adjusted) registered by bioelectrical impedance analysis.
       PATIENTS: This investigation presents data from 10 perinatally HIV-
       infected children, age 7-10 years. 3 children are classified as P1
       (CDC), 4 children as P2 (CDC) and 3 as AIDS. RESULTS: All patients in P1
       showed normal CD4(+) cell count, no p-24 Antigen and non SI virus
       strain. All patients in P2 had CD4(+) cell count > 250/microliters, in
       one child p-24 Ag > 100 pg/ml and in one patient SI-virus strains was
       found. All patients in AIDS had CD4(+) cell count < 250/microliters and
       p-24 Ag > 100 pg/ml, in all children SI-virus strain were found.
       Patients in P1 and P2 showed normal LBM. In patients with AIDS LBM was
       over 80%. DISCUSSION: A single parameter seems not to be sufficient to
       estimate HIV progression. Long term surviver showed no significant
       alterations in all 4 parameters. Beside CD4 cell decline the occurrence
       of SI virus strains was the most specific among the score-parameters in
       heralding rapid disease progression. Results and multivariance-analysis
       of all score-parameters will be demonstrated in detail.
 DE    Body Mass Index  Child  Female  Flow Cytometry  Giant Cells/MICROBIOLOGY
       Human  HIV Core Protein p24/ANALYSIS  HIV
       Infections/*DIAGNOSIS/TRANSMISSION  Leukocyte Count  Lymphocyte
       Transformation  Pregnancy  *Pregnancy Complications, Infectious  T4
       Lymphocytes  MEETING ABSTRACT

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       protected by Copyright Law (Title 17, U.S.Code).