Document 2427
 DOCN  M94A2427
 TI    Correlation between timing of rupture of amniotic membranes and risk of
       HIV-1 perinatal transmission.
 DT    9412
 AU    Paiva JV; Hutto C; Antunes C; Scott G; Federal University of Minas
       Gerais, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):307 (abstract no. PC0159). Unique
       Identifier : AIDSLINE ICA10/94370148
 AB    OBJECTIVES: To study the association between duration of rupture of
       amniotic membranes (ROM) and risk of perinatal HIV-1 transmission in a
       group of HIV-1 infected mothers. METHODS: A retrospective review of the
       maternal medical records of 132 HIV-1 infected mothers who along with
       their infants were enrolled in a prospective study of perinatal HIV-1
       transmission was done to obtain labor and delivery data. All of the
       mothers were born in Haiti and delivered at a single metropolitan
       hospital in south Florida between 1986 to 1989 and all denied drug use
       and blood transfusions. The rate of perinatal infection was compared for
       mothers whose rupture of membranes prior the delivery was > 12 hours and
       < 12 hours. RESULTS: 103 (78%) of 132 were delivered by vaginal
       delivery. Thirty-six of 132 (27%) children were infected and, of these,
       11 (30.6%) were delivered vaginally. The trend analysis found that the
       risk of transmission was greater for infants born to mothers whose ROM
       was > 12 hours than for those < 12 hours (OR = 3, x2 = 4.6, p = 0.03).
       For women delivering vaginally, the correlation was greater than for
       women who were delivered by C-section. Other factors e.g. maternal age,
       maternal lymphocytes count, scalp electrode use, episiotomy, type of
       delivery that may be associated with transmission were also evaluated.
       CONCLUSION: These data suggest that prolonged rupture of membranes in
       HIV-1 infected women delivering vaginally is a risk factor for perinatal
       transmission of virus. The increased risk is presumable due to the
       infant's exposure to maternal cervical and vaginal secretion and blood
       during labor and delivery.
 DE    Delivery  Female  Fetal Membranes, Premature Rupture/*COMPLICATIONS
       Human  HIV Infections/*TRANSMISSION  *HIV-1  Infant, Newborn  Pregnancy
       *Pregnancy Complications, Infectious  Prospective Studies  Retrospective
       Studies  Risk Factors  MEETING ABSTRACT

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