Document 2478
 DOCN  M94A2478
 TI    Sperm parameters in HIV-1 infected patients.
 DT    9412
 AU    Rossi T; Mazzilli F; D'Offizi G; Rosso R; Pinter E; Sarandrea N; Dondero
       F; Aiuti F; 5th Medical Clinic Univ. of Rome La Sapienza.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):295 (abstract no. PC0107). Unique
       Identifier : AIDSLINE ICA10/94370097
 AB    OBJECTIVE: Semen is considered to be an important vehicle in HIV
       transmission. In our study we performed a longitudinal study of semen
       parameters in HIV infected patients and in high risk group to identify
       functional alterations of sperm in HIV+ patients and to establish
       whether these could precede seroconversion. METHODS: We selected 16 HIV+
       patients (4 CDC II, 4 CDC III, 8 CDC IVC2), 36 high risk seronegative
       for HIV subjects, 30 potential semen donors. Semen analysis, the
       hypoosmotic swelling test, the neutral red test and seminal plasma
       biochemical analysis were performed according to WHO standards. RESULTS:
       85% of HIV+ patient showed an alteration of the sperm kinetic properties
       (44% of high risk subjects). Viscosity is increased in about 50% of HIV+
       patients compared to 25% of high risk subjects. In both group, HIV+
       patients and high risk subjects there was a significant increase of the
       percentage of leukocytes and prevalence of peroxidase positive cells
       (high risk subjects). 44% of HIV+ (22% of high risk subjects) showed
       high level of spermiophage cells. DISCUSSION AND CONCLUSIONS: Physical
       seminal parameters in HIV-1 infected patients are modified according to
       CDC stage. Our preliminary data indicate: 1) increased viscosity is
       probably due to the phlogosys of the adnexal glands of the genital tract
       even in asymptomatic patients; 2) early failure of epididymal function
       and 3) an increased level of spermiophage cells perhaps involved in the
       sexual transmission of HIV-1.
 DE    Human  HIV Infections/*TRANSMISSION  HIV Seropositivity  *HIV-1
       Longitudinal Studies  Male  Semen/CHEMISTRY/CYTOLOGY
       Spermatozoa/*PHYSIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).