Document 2488
 DOCN  M94A2488
 TI    Trends in urethritis incidence among HIV-infected homosexual men in the
       SEROCO French cohort.
 DT    9412
 AU    Meyer L; Creusvaux H; INSERM U292, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):292 (abstract no. PC0093). Unique
       Identifier : AIDSLINE ICA10/94370087
 AB    OBJECTIVE: To study trends in urethritis incidence among HIV-infected
       homosexual men in a French multicentric cohort (SEROCO) 1988-1992.
       METHODS: Since 1988, 1036 men with known date of infection or with a
       first positive test in the 12 months before recruitment were included.
       Medical and sexual behaviour history was recorded at each follow-up
       visit. Sexual orientation was self-defined as homo (n = 471), bi (n =
       216) or heterosexual (n = 349). Rates in urethritis incidence (per 100
       person-years (PY)) during the follow-up were computed for each year of
       observation between 1988 and 1992. RESULTS: Among homosexual men,
       urethritis incidence rate during the whole follow-up was 3.4/100 PY. It
       has increased from 2.1 in 1988 to 4.6/100 PY in 1991. When stratified
       according to year of inclusion, data show a same pattern of increase
       among those included in 1988 or in 1989. On the opposite, those included
       after 1989, who tended to be younger, experienced a higher urethritis
       incidence during the whole follow-up than those included before (8.2/100
       PY vs 2.5, p < 0.05), which tended to decrease from 13.0 at inclusion in
       1990 to 7.7/100 PY in 1991. The increase in urethritis rate observed in
       the cohort can be attributed to transmission through unprotected anal
       sex since a decrease in the percentage of cases of urethritis where use
       of condom was systematic was observed. In 90 to 100% of cases according
       to the year, HIV status of at least one of the sexual partners was
       unknown or negative. In 1992 increase in incidence rate in homosexual
       men was not sustained (2.4/100PY). Among bi and heterosexual men in the
       cohort, urethritis incidence was lower (incidence rate during the whole
       follow-up of respectively 2.8 and 1.6/100 PY) and no trend was observed.
       CONCLUSION: The increasing incidence in urethritis observed between 1988
       and 1991 among this French cohort of HIV-infected homosexual men is a
       combination of an increase among those included in 1988-1989 and of the
       recent recruitment of more at-risk men. Analysis of HIV status of the
       partners and condom use shows evidence of on-going risk of HIV
       transmission among the population of homosexual men. Rates in 1993 and
       characteristics of men with urethritis during the follow-up are under
       study.
 DE    Cohort Studies  France/EPIDEMIOLOGY  Homosexuality/*STATISTICS & NUMER
       DATA  Human  HIV Infections/*COMPLICATIONS/EPIDEMIOLOGY/TRANSMISSION
       Incidence  Male  Sex Behavior  Urethritis/COMPLICATIONS/*EPIDEMIOLOGY
       MEETING ABSTRACT  MULTICENTER STUDY

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