Document 2491
 DOCN  M94A2491
 TI    Factors influencing cytomegalovirus infection among HIV+ patients with
       known date of infection. SEROCO Study Group.
 DT    9412
 AU    Carre N; Deveau C; Persoz A; Rouzioux C; Colasante U; Salmon-Ceron D;
       Bucquet D; INSERM U292, Paris, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):292 (abstract no. PC0094). Unique
       Identifier : AIDSLINE ICA10/94370084
 AB    OBJECTIVE: To assess factors influencing the prevalence and incidence of
       CMV infection through a French cohort (SEROCO) of non hemophiliac
       HIV-infected adult patients with known date of HIV-infection. METHODS:
       The date of HIV infection was the mid-point of a maximum two years
       interval between HIV-/HIV+ serology, or the date of a well documented
       HIV primary infection (n = 545). Prevalence of CMV infection was defined
       by the presence of CMV IgG antibody (ELISA) at first visit, and CMV
       incidence by the seroconversion to CMV at a biannual visit among
       initially negative patients (n = 83). Influence of covariates related to
       sexual behavior on prevalence and incidence of CMV infection were
       assessed by a logistic regression and a Cox model. RESULTS: TABULAR
       DATA, SEE ABSTRACT VOLUME. No association was shown with sexually
       transmitted disease (std)(p = 0.1) and sex (p = 0.4). Incidence of CMV
       seroconversion (17/83), after a mean of follow-up of 33 months, was 8.6
       per 100 person-years (py). After taking into account age, occurrence of
       a std, sex with at least a casual partner, high risk behaviour, the only
       predictive variable of CMV seroconversion was homosexual behavior [R.R =
       2.9, p < 0.05] relative to heterosexual behavior. CONCLUSION:
       HIV-infected patients engaged in homosexual practices have an increased
       risk of CMV seroconversion relative to those engaged in heterosexual
       practices independently of occurrence of std, having sex with at least a
       casual partner or having a high risk behaviour.
 DE    Adult  AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY  Blood
       Transfusion  Cytomegalovirus Infections/*COMPLICATIONS/EPIDEMIOLOGY
       France/EPIDEMIOLOGY  Human  Incidence  Prevalence  Risk Factors  Sex
       Behavior  Substance Abuse, Intravenous/COMPLICATIONS  Time Factors
       MEETING ABSTRACT  MULTICENTER STUDY

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