Document 2532
 DOCN  M94A2532
 TI    Slower heterosexual spread of HIV-2 compared with HIV-1.
 DT    9412
 AU    Kanki PJ; Mboup S; Travers K; Marlink R; Siby T; Essex M; Harvard School
       of Public Health, Boston, MA.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):282 (abstract no. PC0050). Unique
       Identifier : AIDSLINE ICA10/94370043
 AB    OBJECTIVE: Based on similar virologic properties, human immunodeficiency
       virus type 2 (HIV-2) has been considered as infectious and capable of
       inducing AIDS as HIV-1. It is therefore important to understand the
       transmission properties of HIV-2 in order to more accurately predict
       this virus' contribution to the growing AIDS pandemic. The measurement
       of HIV incidence is critical to our understanding the dynamics of both
       HIV-1 and HIV-2 spread in populations at-risk and future design of
       vaccine efficacy trials. METHODS: Since 1985, we have prospectively
       studied 1452 registered female prostitutes in Dakar, Senegal, with
       sequential evaluation of their antibody status to HIV-1 and HIV-2.
       Incidence rates of HIV seroconversion were calculated annually and over
       the study period. Poisson regression models were used to describe
       temporal changes in HIV incidence and demographic variables associated
       with seroconversion. RESULTS: From 1985 to 1993, the overall incidence
       of HIV-2 was 1.11/100 person-years (pyo) (95% CI 0.83-1.48), and also
       1.11/100 pyo for HIV-1 (95% CI 0.83-1.48). In this limited analysis,
       risk-factors for infection differed between HIV-1 and HIV-2. Over the
       8-year period, the annual incidence of HIV-2 remained stable, despite
       higher HIV-2 prevalence. Over the 8 year period, the annual incidence of
       HIV-1 dramatically increased, with a 1.4 fold increased risk per year
       and thus a 12-fold increase over the study period. CONCLUSION: In our
       study population, the heterosexual spread of HIV-2 is significantly
       slower than that of HIV-1, which strongly suggests differences in the
       infectivity potential of these two related immunodeficiency viruses.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/MICROBIOLOGY/
       *TRANSMISSION  Female  Human  *HIV-1  *HIV-2  Incidence  Prospective
       Studies  Prostitution  Risk Factors  Senegal/EPIDEMIOLOGY  *Sex Behavior
       MEETING ABSTRACT

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