Document 2534
 DOCN  M94A2534
 TI    HIV-1 and HIV-2 status in Ghanaian AIDS and ARC patients.
 DT    9412
 AU    Ayisi KN; Ishikawa K; Magnusen AF; Sata T; Mensah M; Noguchi Memorial
       Inst. for Med. Res. Ghana.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):282 (abstract no. PC0049). Unique
       Identifier : AIDSLINE ICA10/94370041
 AB    We have used the particle agglutination (PA) test, Western blot (WB)
       test, polymerase chain reaction (PCR) test and virus isolation to define
       human immunodeficiency virus (HIV) status of 17 acquired immune
       deficiency syndrome (AIDS), 6 AIDS related complex (ARC), and 2
       asymptomatic Ghanaians. HIV-1 antibodies were more frequently detected.
       PCR detected HIV-1 and HIV-2 proviral DNA in 81.2% (13/16) and 18.8%
       (3/16) respectively of HIV positive samples. Of the 12 viruses isolated,
       9 were HIV-1, 2 were HIV-2 and both HIV-1 and HIV-2 were isolated from
       one individual. Two of the HIV-1 isolates were from ARC patients who
       have been either HIV-1 or HIV-2 indeterminate for more than one year
       without becoming seropositive. Our results indicate that HIV-1 is now
       predominant in Ghanaian AIDS and ARC patients and that the
       serodiagnostic window for HIV detection in Ghana may extend beyond one
       year or that antigens in commercially available kits may not detect
       antibodies to certain strains of HIV in Ghana.
 DE    Acquired Immunodeficiency Syndrome/*MICROBIOLOGY  Agglutination Tests
       AIDS-Related Complex/*MICROBIOLOGY  Blotting, Western  Ghana  Human
       HIV-1/*ISOLATION & PURIF  HIV-2/*ISOLATION & PURIF  Polymerase Chain
       Reaction  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).