Document 2570
 DOCN  M94A2570
 TI    Epidemiological model of recent introduction of HIV in a virgin
       population. HIV infection of children in north-east Romania.
 DT    9412
 AU    Apetrei C; Mitrol I; Buzdugan I; Iancu L; Strat L; Macovel O; State E;
       Sumucluc I; Duca M; Virus Laboratory, University of Medicine, Iasi,
       Romania.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):274 (abstract no. PC0017). Unique
       Identifier : AIDSLINE ICA10/94370005
 AB    BACKGROUND: Since 1990, a number of studies shows that in Romania, for
       the time being, the HIV epidemic recognise an epidemiological pattern
       quite different from all other described ways of evolution. The
       characteristics of this pattern are: the great number (90%) of HIV/AIDS
       of recorded cases are children less than 12 year old; in the
       investigated area. HIV-infection is revealed only in children up to 5,
       born to seronegative mothers and nursed in orphanages. OBJECTIVES: 1. To
       determine the actual prevalence of HIV infection in children's homes and
       the stage of illness in the already infected children. 2. To screen for
       HIV all accessible mothers of the HIV infected children, as well as
       blood donors and persons in risk for HIV-infection (transfused before
       1989, dialyzed, pregnant women, persons with venereal diseases and
       tuberculosis). 3. Evaluating the efficiency of routine control measures
       of horizontal HIV transmission. PATIENTS AND METHOD: Sera from 2355
       children, aged 1 month--19 years, from nursing homes; 65,000 blood
       donors, 132 transfused patients, 400 venereal diseases patients; 4,212
       pregnant women, 70 patients with tuberculosis. Serological method
       consisted of ELISA screening (HIV1 + 2--WELLCOME and GENELAVIA
       MIXT--SANOFI DG. PASTEUR), retesting of reactive sera by indirect ELISA
       (DETECT HIV--IAF BIOCHEM); repeated reactive sera in ELISA were
       confirmed by WB (DG. PASTEUR). Statistical processing was done using EPI
       Info software. RESULTS: From all adults tested, only sera from two
       patients with tuberculosis were positive for HIV1. 42 children, aged 0-6
       years (mean 2.14+/-0.32) were proved to be seropositive. All tested
       mothers were seronegative. Early HIV-seroconversion in 3 children (2
       twin boys aged 4 months and a female child of 6 weeks), born to
       HIV-seronegative mothers, was revealed in the Newborn Intensive Care
       Unit. CONCLUSIONS: 1. The epidemiological data here described are
       demonstrative for recent introduction of HIV1 and the initial period of
       development of the HIV epidemic. 2. Usual measures of hygiene,
       decontamination and asepsy, control of blood donations, reduction of
       transfusions and of parenteral medical practices succeeded in
       interruption of resurgence of new cases of HIV-infection in the observed
       children settings.
 DE    Adolescence  Adult  AIDS Serodiagnosis  Child  Child, Preschool
       Enzyme-Linked Immunosorbent Assay  Female  Human  HIV
       Infections/DIAGNOSIS/*EPIDEMIOLOGY/TRANSMISSION  Infant  Male  Pregnancy
       Pregnancy Complications, Infectious/EPIDEMIOLOGY  Prevalence  Risk
       Factors  Romania/EPIDEMIOLOGY  MEETING ABSTRACT

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