Document 2584
 DOCN  M94A2584
 TI    Trends in antimicrobial susceptibility patterns for N. gonorrhoeae in
       Kumasi, Ghana.
 DT    9412
 AU    Addy PA; Dept. of Clinical Microbiology, UST School of Medical
       Sciences,; Kumasi, Ghana.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):270 (abstract no. PB0508). Unique
       Identifier : AIDSLINE ICA10/94369991
 AB    OBJECTIVE: The study aims to determine the susceptibility patterns of
       seven (7) oft-prescribed antimicrobial agents for the treatment of
       gonorrhoea in Kumasi, Ghana. METHODS: One thousand, one hundred and
       eighty-seven (1187) patients from whom specimens (high vaginal, cervical
       and urethral swabs) containing Gram negative intracellular diplococci
       (GNID) amidst polyphonuclear leukocytes were identified constituted the
       study population whilst the specimen, the study material. Identity of N.
       gonorrhoeae was confirmed by colonial morphology, positive oxidase test
       and sugar fermentation pattern. Penicillinase producing N. gonorrhoeae
       (PPNG) strains were determined by the Intralactam Strip method. Minimal
       Inhibitory Concentrations (MICs) of seven (7) antimicrobial agents were
       determined by the agar plate dilution method. RESULTS: Of 1187 N.
       gonorrhoeae strains isolated, 93.93% were PPNG. The disc diffusion
       Antibiotic sensitivity test results showed that Ceftriaxone (100%) and
       Norfloxacin (99.50%) were the most effective antimicrobials against
       gonorrhoea, inhibiting all 300 selected PPNG strains at MICs of < or =
       0.03 mg/L. and < or = 0.5 mg/L., respectively. Over 60% of the isolates
       were sensitive to Erythromycin, Spectinomycin, and Tetracycline.
       Isolated PPNG as well as non-PPNG strains, were 100% resistant to
       Septrin. With Penicillin, only 72 non-PPNG strains were inhibited at a
       MIC of 32.0 mg/L. Erythromycin, Tetracycline and Spectinomycin inhibited
       all 300 selected PPNG strains at MICs of < or = 32.0 mg/L., < or = 4.0
       mg/L. and < or = 16.0 mg/L., respectively. DISCUSSIONS AND CONCLUSIONS:
       There is a high incidence of PPNG in Ghana. A review of the current
       Gonorrhoea Treatment Regimen needs be undertaken. Suggestions to this
       end have been made.
 DE    Antibiotics/*THERAPEUTIC USE  Ceftriaxone/THERAPEUTIC USE  Comparative
       Study  Female  Ghana  Gonorrhea/*DRUG THERAPY/MICROBIOLOGY  Human  Male
       Microbial Sensitivity Tests  Neisseria gonorrhoeae/*DRUG EFFECTS
       Norfloxacin/THERAPEUTIC USE  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).