Document 2598
 DOCN  M94A2598
 TI    Cervical dysplastic lesions among HIV-seropositive pregnant women.
 DT    9412
 AU    Spinillo A; Iasci A; Maccabruni A; Piazzi G; Nicola S; Baltaro F;
       Department of Obstetrics and Gynecology, University of Pavia,; Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):268 (abstract no. PB0501). Unique
       Identifier : AIDSLINE ICA10/94369977
 AB    OBJECTIVE: To evaluate the frequency and natural history of cervical
       intraepithelial neoplasia (CIN) during pregnancy in women with human
       immunodeficiency virus type 1 (HIV-1) infection. METHODS: We evaluated
       prospectively 23 pregnant HIV-1 seropositive patients and 18
       HIV-seronegative controls. Follow-up visits were carried-out each
       trimester of pregnancy and 8-12 weeks post-partum with Papanicolaou
       smears, colposcopic examinations and, when necessary, colposcopically
       directed cervical biopsies. In situ hybridization to detect human
       papillomavirus DNA types 6/11, 16/18 and 31/35/51 was performed on
       cervical biopsies with biotinylated probes. During pregnancy, in the
       absence of signs of progression, squamous intraepithelial cervical
       lesions were managed conservatively. RESULTS: Eight of 23 (34.8%)
       HIV-seropositive women and 2 of 18 (11.1%) HIV-seronegative controls had
       biopsy-proven CIN (P = 0.08 by Fisher exact test). Cervical carcinoma in
       situ (CIN III) was detected in 5 cases (21.7%) and in none of the
       controls (P = 0.04 by Fisher exact test). All the severe lesions stained
       positive for human papillomavirus types 31/35/51. None of the cervical
       squamous intraepithelial lesions progressed throughout pregnancy, in
       both cases and controls. Post-partum cold-knife cervical conization was
       performed on 5 patients with CIN III. Examination of the conization
       specimens demonstrated persistence of CIN III with the same viral types
       identified on preconization biopsy specimens. CONCLUSIONS:
       HIV-seropositive women are at high risk of CIN during pregnancy. Our
       preliminary data suggest that the progression rate of CIN during
       gestation is low.
 DE    Adult  Biopsy  Cell Transformation, Neoplastic/PATHOLOGY  Cervical
       Intraepithelial Neoplasia/PATHOLOGY  Cervix Dysplasia/*PATHOLOGY  Cervix
       Neoplasms/*PATHOLOGY  Cervix Uteri/PATHOLOGY  Female  Follow-Up Studies
       Human  HIV Seropositivity/*PATHOLOGY  *HIV-1  Neoplasm Staging
       Pregnancy  Pregnancy Complications, Infectious/*PATHOLOGY  Pregnancy
       Complications, Neoplastic/*PATHOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).