Document 2599
 DOCN  M94A2599
 TI    Evaluating sensitivity in vitro and in vivo of Neisseria gonorrhoea to
       kanamycin in STD patients in Mozambique.
 DT    9412
 AU    De Hulsters B; Noya A; Bastos R; Crucitti T; Foigosa E; Barretto A;
       National STD/AIDS Control Programme, Ministry of Health, Maputo,;
       Mozambique.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):268 (abstract no. PB0502). Unique
       Identifier : AIDSLINE ICA10/94369976
 AB    INTRODUCTION: STDs are one of the most common causes for consultation in
       Mozambique. Up to one third of these consultations are males with
       urethral discharge. The treatment of acute purulent discharge in men had
       been established by the National STD Control Programme in 1987 with
       Kanamycin 2 g IM, after a study on its therapeutic efficiency. Since
       then no further monitoring of its efficiency has been done. It was
       therefore decided that an evaluation was in order, as may strains
       resistant to Kanamycin are appearing in other countries. OBJECTIVES: A
       study protocol was therefore drawn up to assess its in vitro and in vivo
       susceptibility to Kanamycin, and in vitro to Kanamycin, penicillin and
       spectinomycin. METHODS: Four different cities were selected to
       contribute to the evaluation of 800 cultures of gonococci of male
       patients with acute, untreated purulent urethritis. A final confirmation
       and a first MIC were done at the reference laboratory in Maputo. The MIC
       was thereafter confirmed in the laboratory of Antwerp Tropical
       Institute. RESULTS: The collection and analysis of samples will be
       realized between January and July 1994. The results will be used to
       decide wether or not alteration of treatment strategies will be
       necessary in the future in Mozambique. A more regular surveillance of
       the sensitivity of N. gonorrhoea will thereafter be installed, to assure
       sound treatment schedules which remain cost effective and efficient.
 DE    Dose-Response Relationship, Drug  Gonorrhea/*DRUG THERAPY  Human
       Injections, Intramuscular  Kanamycin/*THERAPEUTIC USE  Male  Microbial
       Sensitivity Tests  Mozambique  Neisseria gonorrhoeae/*DRUG EFFECTS
       Penicillins/THERAPEUTIC USE  Spectinomycin/THERAPEUTIC USE  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).