Document 2601
 DOCN  M94A2601
 TI    Nucleolar organizer regions-associated proteins in cervical dysplastic
       lesions from HIV-seropositive women.
 DT    9412
 AU    Spinillo A; Iasci A; Barbarini G; Tenti P; Piazzi G; Baltaro F;
       Department of Obstetrics and Gynecology, IRCCS S. Matteo, Pavia,; Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):267 (abstract no. PB0498). Unique
       Identifier : AIDSLINE ICA10/94369974
 AB    OBJECTIVE: To evaluate the proliferative activity of cervical
       intraepithelial neoplasia (CIN) lesions in Human Immunodeficiency Virus
       (HIV) seropositive women. METHODS: The proliferative activity of CIN
       lesions was measured by nucleolar organizer regions-associated proteins
       (AgNORs) count. Twenty-two biopsy specimens of CIN lesions from HIV
       positive patients were compared with 22 matched biopsies obtained from
       HIV-negative controls. RESULTS: The mean count of AgNORs per cell was
       9.5 +/- 3.7 (SD) in HIV-positive patients and 7.6 +/- 2.8 in
       HIV-negative controls (P < .0001 by Poisson test of heterogeneity of
       counts). The difference in AgNOR counts between the two groups, which
       was confirmed by log-linear analysis, persisted within each severity
       stratum of CIN and was independent of associated Human Papillomavirus
       infection. In HIV-positive patients, log-linear analysis showed that
       high grade CIN, presence of HPV infection, and severity of HIV disease
       were independently correlated with increased AgNOR counts per cell.
       CONCLUSIONS: The results of the present study indicate that the
       proliferative activity of CIN lesions of HIV-positive patients was
       increased when compared with matched lesions from HIV-negative women.
       This finding suggests the possibility of an increased oncogenic
       progression of CIN lesions in HIV-positive patients.
 DE    Biopsy  Cell Division/PHYSIOLOGY  Cervical Intraepithelial
       Neoplasia/*PATHOLOGY  Cervix Dysplasia/*PATHOLOGY  Cervix
       Neoplasms/*PATHOLOGY  Cervix Uteri/PATHOLOGY  Female  Human  HIV
       Seropositivity/*PATHOLOGY  Neoplasm Invasiveness  Nuclear
       Proteins/*ANALYSIS  MEETING ABSTRACT

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