Document 2608
 DOCN  M94A2608
 TI    Vaginal fluid collected with OMNI-SAL collection device as an
       alternative to serum for immunodiagnosis.
 DT    9412
 AU    Singh N; Singh S; Deptt of Lab. Medicine, All India Inst. of Medical
       Sciences, New; Delhi.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):265 (abstract no. PB0489). Unique
       Identifier : AIDSLINE ICA10/94369967
 AB    INTRODUCTION: Blood collection and processing, for serological diagnosis
       of infectious diseases like HIV, HBV, HSV etc. has got potential risk of
       hospital acquired infection. Saliva has been advocated as an alternative
       of the serum for immunological assays. We further extended this
       possibility to vaginal fluids to use it as clinical specimen for TORCH
       antibody determination. METHODS: Serum, saliva and vaginal fluids from
       25 women (aged 20-30) were tested for TORCH antibody profiles. The
       saliva and vaginal fluids were collected using the OMNI-SAL collection
       device. The antibody concentration in all the three body fluids were
       compared. RESULTS: The antibody concentration in vaginal fluids were
       more than saliva but less than serum for Toxoplasma, Rubella, CMV and
       HSV infections. However, anti-toxoplasma specific IgA antibody levels
       were almost same in vaginal fluids and serum. CONCLUSIONS: Vaginal fluid
       can be used as an alternative to the serum. Unlike saliva, in vaginal
       fluid, there are no fluctuations in the concentration during eating,
       drinking or emotions. Moreover, detection of IgA antibodies in vaginal
       fluids is more pertinent in prevention of sexually transmitted diseases.
 DE    Adult  Antibodies/*ANALYSIS  Comparative Study  Cytomegalovirus
       Infections/*IMMUNOLOGY  Female  Herpes Simplex/*IMMUNOLOGY  Human  IgA,
       Secretory/METABOLISM  Predictive Value of Tests  Rubella/*IMMUNOLOGY
       Saliva/IMMUNOLOGY  Toxoplasmosis/*IMMUNOLOGY  Vagina/*IMMUNOLOGY
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).