Document 2620
 DOCN  M94A2620
 TI    Usefulness of indirect enzyme immunoassay for diagnosis of chlamydial
       infections in infants.
 DT    9412
 AU    Yamazaki T; Nozomu S; Honda A; Nakada H; Saitama Medical School, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):262 (abstract no. PB0477). Unique
       Identifier : AIDSLINE ICA10/94369955
 AB    Chlamydia trachomatis (C. trachomatis) is transmitted from mothers to
       children and causes conjunctivities and respiratory infections among
       infants. We evaluated Determiner Chlamydia, which is an indirect enzyme
       immunoassay, for an epidemiological study of vertical transmission of C.
       trachomatis. Pregnant women were examined by Chlamydiazyme (Abott) using
       endcervical swabs. Maternal and cord bloods were taken for detection of
       IgG and IgA antibodies against C. trachomatis, by Determiner Chlamydia
       (Chiba Serum Institute). Pregnant women were classified into 3 groups as
       follows. Group 1 (n=10): Ag(+), IgG(+), IgA(+), Group 2 (n=8): Ag(+),
       IgG(+), IgA(-), Group 3 (n=16): Ag(-), IgG(+), IgA(+). Babies from each
       group were followed up for clinical symptoms, chlamydial antigens and
       serum antibodies. Three infants from Group 1 and one from Group 2
       mothers showed increased IgA by Determiner Chlamydia after 3 months of
       age. All 4 infants had respiratory symptoms and chlamydial antigens were
       detected from respiratory tract. None of cord bloods was positive for
       IgA antibody. Determiner Chlamydia is easy to perform and is useful
       method for diagnosis of respiratory infections during early infancy.
       Significance of IgA antibody for C. trachomatis infection should be
       studied further.
 DE    Antibodies, Bacterial/BLOOD  Antigens, Bacterial/BLOOD  *Chlamydia
       trachomatis/IMMUNOLOGY  Chlamydia
       Infections/*CONGENITAL/DIAGNOSIS/IMMUNOLOGY  Female  Human  IgA/BLOOD
       IgG/BLOOD  *Immunoenzyme Techniques  Infant, Newborn
       Pneumonia/CONGENITAL/DIAGNOSIS/IMMUNOLOGY  Pregnancy  Pregnancy
       Complications, Infectious/*DIAGNOSIS/IMMUNOLOGY  MEETING ABSTRACT

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