Document 2622
 DOCN  M94A2622
 TI    HIV infection in children: mucocutaneous manifestations.
 DT    9412
 AU    el Hachem M; Castelli G; Pianosi G; Krzysztofiak A; Livadiotti S; Ferri
       M; Bambino Gesu Children Hospital, I.R.C.C.S., Rome, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):262 (abstract no. PB0479). Unique
       Identifier : AIDSLINE ICA10/94369953
 AB    OBJECTIVE: Studies in adult suggest that mucocutaneous diseases are more
       common in patients with HIV-1 infections or AIDS than in other persons.
       The authors analyze differences in clinical course, severity and
       persistence of mucocutaneous symptoms in children with HIV infection and
       AIDS. RESULTS: The authors reviewed clinical records of 166 HIV-1
       seropositive children, observed at Bambino Gesu children's Hospital in
       Rome between 1990-1993. One hundred of them are infected (53 have AIDS),
       and 66 were HIV positive at birth but not infected. For the whole length
       of the study 46 (46%) infected patients showed one or more mucocutaneous
       diseases with 114 clinical manifestations (mean 2.8/patient). Out of the
       66 HIV seropositive but not infected children only 9 (14%) had
       mucocutaneous diseases. Fungal infection (Candida) followed by viral
       diseases such as Warts (8), Molluscum contagiosum (5) and Herpes (5) was
       the most frequent diseases. DISCUSSION: In pediatric age the most
       frequent mucocutaneous manifestations are infections, while the non
       infective manifestations common in adults, as Kaposi and Sebhorroic
       dermatitis, are exceptional in children. Also the common diseases, such
       as Herpes simplex or fungal infection, often required laboratory
       analysis or a mucocutaneous biopsy to be diagnosed because clinical
       evidence are not typical. The majority of them are resistant to
       conventional therapy. CONCLUSION: Mucocutaneous diseases are extremely
       common in HIV-1 infected children. Their incidence increases as immune
       function deteriorates. The clinical aspects of the skin disease is often
       atypical with diagnostic difficulties and therapy resistance.
 DE    Acquired Immunodeficiency Syndrome/*DIAGNOSIS/EPIDEMIOLOGY  AIDS-Related
       Opportunistic Infections/*DIAGNOSIS/EPIDEMIOLOGY  Child  Child,
       Preschool  Cross-Sectional Studies  Human  HIV
       Infections/*DIAGNOSIS/EPIDEMIOLOGY  *HIV-1  Incidence  Infant  Infant,
       Newborn  Italy/EPIDEMIOLOGY  Skin Diseases,
       Infectious/*DIAGNOSIS/EPIDEMIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).