Document 2632
 DOCN  M94A2632
 TI    Title: Papanicolaou (PAP) smears versus colposcopy as screening tests
       for cervical intraepithelial neoplasia (CIN) in HIV seropositive women.
 DT    9412
 AU    Norton D; Brosgart C; Barkin M; Zaloudek C; Palefsky J; Padian N;
       Greenblatt R; East Bay AIDS Center, Berkeley, CA 94705.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):26 (abstract no. 079B). Unique
       Identifier : AIDSLINE ICA10/94369943
 AB    OBJECTIVE: To compare the results of pap smears versus colposcopy as a
       screening test for cervical intraepithelial neoplasia (CIN) in HIV
       seropositive women. METHODS: Sample 100 HIV positive and 50 HIV negative
       women, pregnant women excluded. Between 4/93 and 2/94, 76 HIV positive
       and 20 HIV negative women enrolled. Exam includes consent, complete
       history and physical exam. CD4, pelvic exam with pap smear and
       colposcopy, screening tests for STD's (HIV, HPV, RPR, chlamydia,
       candida, bacteria and trichomonas), and directed cervical biopsies as
       indicated, are performed at enrollment, 6 months and 12 months. At study
       completion, all HIV positive women will be offered enrollment in a
       long-term natural history study of women with HIV disease. FINDINGS: 40%
       of HIV positive women have abnormal pap smears at entry compared to 10%
       of controls; 37% of HIV positive women had abnormal Colposcopic exams
       compared to 10% of controls. 59% of Negative pap smears in HIV positive
       women are positive for oncogenic types of HPV. 60% of women with
       negative pap smears are positive for HPV. CONCLUSIONS: There is good
       correlation between the results of pap smear as compared to colposcopy
       in screening for CIN in HIV positive women. At study completion, data
       will be available in regards to the recommended frequency of cervical
       screening on HIV positive women (6 versus 12 months).
 DE    Carcinoma in Situ/COMPLICATIONS/*DIAGNOSIS  Cervix
       Neoplasms/COMPLICATIONS/*DIAGNOSIS  Cervix Uteri/MICROBIOLOGY
       *Colposcopy  Comparative Study  Female  Human  HIV Seronegativity  HIV
       Seropositivity/*COMPLICATIONS  Papillomavirus, Human/ISOLATION & PURIF
       Sensitivity and Specificity  *Vaginal Smears  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).