Document 2640
 DOCN  M94A2640
 TI    Parotid swelling in children with HIV infection.
 DT    9412
 AU    Tucci F; Castelli G; Bottero S; Scaccia S; Livadiotti S; Bernardi S;
       Krzysztofiak A; Mattia S; Elia L; Bambino Gesu Children Hospital, Rome,
       Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):258 (abstract no. PB0462). Unique
       Identifier : AIDSLINE ICA10/94369935
 AB    OBJECTIVE: To investigate clinical, immunological and imaging features
       of parotid enlargement in children infected with HIV. MATERIALS: 22
       patients were studied (12 M and 10 F) out of 90 HIV infected children
       between 17 months and 14 years old, with evidence of chronic parotid
       gland swelling (8 vertically infected and 2 by blood transfusion) and
       followed for a mean period of 20 mths. At entry nobody fulfilled the CDC
       AIDS definition but 6 patients presented LIP. All the children were
       studied with echography; 7 patients were also studied with sialo-TC.
       RESULTS: Almost all the children had bilateral parotid swelling which
       appeared at a mean age of 4 years (range 17-80 mm) in the vertically
       infected and after 6 years from the infection in the two transfused.
       Pulmonary lymphoid hyperplasia was revealed in 6 patients. CD4/CD8 ratio
       was reversed in all the children (mean 0.47). Sonographic images showed
       small diffused hypoechoic areas in all patients and in 4 large anechoic
       areas almost totally replacing gland. Follow-up clinical examinations of
       patients showed a slow evolution in 5 cases, spontaneous regression in 1
       and recurrent infections with suppuration in 3. Superficial monolateral
       and bilateral parotidectomy was performed in these cases and in one of
       the histological diagnoses of B cell lymphoma occurred. This child is
       still well after 2 years. CONCLUSIONS: Parotid swelling seems to be
       associated with milder clinical courses but in patients with evidence of
       large cystic areas a surgical approach to prevent recurrent infection or
       neoplasm could be indicated.
 DE    Adolescence  AIDS-Related Opportunistic
       Infections/ETIOLOGY/*ULTRASONOGRAPHY  Child  Child, Preschool  Female
       Follow-Up Studies  Human  Hyperplasia  HIV
       Infections/TRANSMISSION/*ULTRASONOGRAPHY  Infant  Italy  Lymphoma,
       AIDS-Related/SURGERY/ULTRASONOGRAPHY  Male  Parotid
       Diseases/ETIOLOGY/*ULTRASONOGRAPHY  Parotid
       Gland/PATHOLOGY/ULTRASONOGRAPHY  Parotid
       Neoplasms/SURGERY/ULTRASONOGRAPHY  Parotitis/ETIOLOGY/*ULTRASONOGRAPHY
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).