Document 2661
 DOCN  M94A2661
 TI    Poor pregnant women and HIV-1 infection: maternal prognosis in a
       Brazilian community.
 DT    9412
 AU    Duarte G; Quintana SM; Gir E; Marana HR; Mussi-Pinhata MM; Clinical
       Hospital of Medicine Scholl of Ribeirao Preto-University; of Sao
       Paulo-Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):253 (abstract no. PB0440). Unique
       Identifier : AIDSLINE ICA10/94369914
 AB    OBJECTIVES: 1) To determine the yearly prevalences of anti-HIV-1
       seropositivity among poor parturients in Ribeirao Preto, Brazil.; 2) To
       evaluate clinically the effects of pregnancy on the HIV-1 infection
       prognosis, considering its clinical stages. METHODS: A prospective
       survey was carried out from 1987 to 1993 among 221 HIV-1 infected
       parturients cared at a University Hospital. The influence of pregnancy
       on the HIV-1 infection prognosis was analysed in 107 parturients based
       specially on clinical parameters (CD4 count not available). The data
       were compared with control groups composed by HIV-1 infected
       non-obstetric female population. Kaplan-Meyer Method and Exact Fisher
       Test were used for statistical analysis. RESULTS: The yearly prevalence
       rates by 1,000 births were: 1.9 in 1987; 5.4 in 1988; 10.8 in 1989; 13.1
       in 1990; 20.6 in 1991; 21.1 in 1992; 21.2 in 1993. A total of 16
       parturients in stages III/IV of HIV-1 infection were followed-up for 17
       months. The mortality rate was higher in this group (55.5%) than in the
       control group (31.2%), specially during the first trimester after the
       delivery. The 91 parturients in stage II were followed-up for 30 months
       In this group the infection had a faster evolution from stage II to IV
       (69.2%), in comparison to the control group (42.9%), mainly after the
       first year of delivery. DISCUSSION AND CONCLUSIONS: The poor maternal
       prognosis observed among these parturients can be the result of HIV-1
       infection in addition to malnutrition, lack of prenatal caring and other
       infections associated. Such conditions are constant in developing
       countries and different from the developed ones. The increasing number
       of anti-HIV-1 seropositive parturients and the compromised maternal
       prognosis observed in these patients do reinforce the need to promote
       counselling that do not stimulate reproduction in this group of women,
       unless an effective therapeutic for HIV infection be discovered.
 DE    Brazil/EPIDEMIOLOGY  *Developing Countries  Female  Follow-Up Studies
       Human  HIV Infections/CLASSIFICATION/*MORTALITY/TRANSMISSION  HIV
       Seroprevalence  *HIV-1  Infant, Newborn  Poverty/*STATISTICS & NUMER
       DATA  Pregnancy  Pregnancy Complications,
       Infectious/CLASSIFICATION/ETIOLOGY/  *MORTALITY  Prospective Studies
       Risk Factors  Survival Analysis  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).