Document 2667
 DOCN  M94A2667
 TI    HIV vertical transmission in Buenos Aires: follow-up.
 DT    9412
 AU    Laube G; Canizal AM; Zarwanitzer S; Hirsch R; Sosa CE; Benetucci J;
       Muniz H; FUNDAI y Pediatria, Buenos Aires, Argentina.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):252 (abstract no. PB0439). Unique
       Identifier : AIDSLINE ICA10/94369908
 AB    OBJECTIVE: To determine the HIV vertical transmission rate in Buenos
       Aires, Argentina and to assess HIV co-culture and p24 Antigen detection
       in early diagnosis of pediatric AIDS. METHODS: Thirty seven children
       born to HIV seropositive mothers were enrolled and prospectively
       followed until they reached 18 months of age to determine HIV infection.
       All children were in a PO clinical status according to CDC at the moment
       of enrollment. Children were studied by EIA (Abbot) and Immunoblot
       (Novapath, Blorad) for HIV antibody detection. Virus co-culture and p24
       Antigen detection (Organon Teknika) were performed in all the samples.
       RESULTS: Nine out of 37 (24.32%) children were infected after 18 months
       of follow up according to HIV antibody detection meanwhile seroreverter
       children lost their antibodies between 7 to 10 months (mean 8.3). Eight
       out of 37 (21.6%) children were positive for virus co-culture and 6/37
       (15.8%) had p24 Antigen detected. Two children out of the ten infected
       developed AIDS Defining Condition: one lymphoid interstitial pneumonia
       and one sepele by Salmonella (deceased) and 37.5% of the infected
       children presented symptomatology before 12 month of age. Mothers' risk
       factors were: 37.66% intra venous drug users and 63.4% heterosexual
       transmission. CONCLUSIONS: The HIV1 vertical transmission rate is 24.32%
       for this population. HIV co-culture showed a good correlation with
       follow up and antigen is a valuable alternative although not as
       sensitive as co-culture. This preliminar report shows lower figures than
       other communications.
 DE    Argentina  AIDS Serodiagnosis  *Developing Countries  Female  Follow-Up
       Studies  Human  HIV Core Protein p24/BLOOD  HIV
       Infections/DIAGNOSIS/*TRANSMISSION  HIV
       Seropositivity/DIAGNOSIS/*TRANSMISSION  Infant  Infant, Newborn
       Pregnancy  Pregnancy Complications, Infectious/*DIAGNOSIS  Prospective
       Studies  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).