Document 2671
 DOCN  M94A2671
 TI    HIV positivity in donated bloods screened negative for HIV antibody,
       Thailand, 1993.
 DT    9412
 AU    Auwanit W; Tenprasert S; Bhumisawadi J; Wael C; Department of Medical
       Sciences, Ministry of Public Health,; Nonthaburi, Thailand.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):251 (abstract no. PB0433). Unique
       Identifier : AIDSLINE ICA10/94369904
 AB    OBJECTIVES: To determine the number of HIV positivity in donated bloods
       routinely screened as negative for HIV antibody at 15 hospital
       laboratories in Thailand, during June 1992 to July 1993. METHOD: During
       June 1992 to July 1993, a total of 73,292 donated bloods at 15
       provincial laboratories in Thailand were routinely screened for HIV
       antibody and HIV-P24 antigen. All reactive specimens for HIV antibody
       and/or P24 antigen were confirmed by supplemental tests (IFA and/or WB
       for HIV antibody and NT for P24 antigen) at the reference laboratory.
       Five percents of donated bloods shown non-reactive screening for both
       HIV antibody and antigen were randomly collected each day from every
       provincial laboratories and were re-tested for HIV antibody and antigen
       by ELISA at the reference laboratory in Bangkok to observe a false
       negative HIV antibody or antigen results. RESULTS: A median value of the
       prevalence of HIV antibody positive blood donors in this study were 2.2%
       (range 0.7-5.8%) in the north, 1.45% (range 0.8-2.1%) in the south, 3.7%
       in the east and 0.6% in the central of Thailand. The rate of HIV-P24
       antigen positive but antibody negative blood donors is 8 per 100,000
       donations. Out of 3,564 blood samples which were randomly collected from
       the seronegative blood donation units screened at provincial
       laboratories, there were 10 blood samples (0.28%) showed HIV antibody
       positive results when re-tested by ELISA screening test at reference
       laboratory. DISCUSSION AND CONCLUSIONS: The results indicated the high
       risk of HIV transmission by blood donation units of the early HIV
       infected donor. The pre-blood donation interview has to be maintained to
       exclude the donor who has risk behaviors. Furthermore, the cost-benefit
       of P24 antigen testing in all blood donation units has to be urgently
       considered. Quality assurance among HIV laboratories as well as a
       quality control of all HIV reagent kits have to be carried out
       continuously to decrease a number of false negative results.
 DE    *Blood Donors  *Developing Countries  False Negative Reactions  Human
       HIV Antibodies/*BLOOD  HIV Core Protein p24/BLOOD  HIV
       Seropositivity/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION  HIV Seroprevalence
       Risk Factors  Thailand  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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