Document 2692
 DOCN  M94A2692
 TI    Evaluation of 7 simple/rapid HIV antibody assays using seroconversion
       panels.
 DT    9412
 AU    Vercauteren G; Beelaert G; Belsey E; Constantine N; van der Groen G;
       Tamashiro H; Institute of Tropical Medicine, Department Infection &
       Immunity,; Antwerpen, Belgium.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):246 (abstract no. PB0415). Unique
       Identifier : AIDSLINE ICA10/94369883
 AB    OBJECTIVE: To evaluate the performance of 7 simple/rapid (S/R) HIV
       antibody assays with visual reading using seroconversion panels.
       METHODS: Seven S/R HIV antibody assays (Immunocomb Bispot, HIV Chek 1 +
       2, Recombigen HIV-1/HIV-2 rapid test device, Serodia HIV-1, Serodia
       HIV-1/2, Capillus HIV1/HIV2, Test pack) were assessed using 11
       seroconversion panels (BBI and Serologicals). Results were compared to
       the Abbott Recombinant HIV-1/HIV-2 3rd generation EIA (reference test)
       which consistently detected antibody at an early time post infection.
       RESULTS: All of the S/R assays detected antibody on the same day as the
       reference test in at least 5 of the 11 panels. Overall, the S/R assays
       detected antibody on the average between 0.5 and 4.2 days later than the
       reference test. On two occasions some of the simple tests were even
       earlier positive than the reference test. One test performed
       significantly worse (p < 0.01) than the reference test. The additional
       risks compared to the reference test of missing an infectious unit of
       blood during seroconversion by using the worst of the simple tests
       ranges from 1 per 100 million to 1 in 100,000 at an incidence of 0.0001%
       and 0.1% respectively. CONCLUSIONS: We conclude that, although there are
       differences in sensitivity between the S/R assays with visual reading
       when used to test blood from individuals during the course of
       seroconversion, the differences are small and comparable with those
       obtained by the more sophisticated ELISA tests.
 DE    AIDS Serodiagnosis/*METHODS  Blood Banks  Comparative Study  Human  HIV
       Seropositivity/*DIAGNOSIS/IMMUNOLOGY  HIV-1/*IMMUNOLOGY
       HIV-2/*IMMUNOLOGY  *Immunoenzyme Techniques  Predictive Value of Tests
       Reference Values  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).