Document 2705
 DOCN  M94A2705
 TI    Is indeterminate western blot in dialysis patients caused by multiple
       transfusions?
 DT    9412
 AU    Yust I; Vardinon N; Katz O; Burke M; Tel Aviv Medical Center, Israel.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):243 (abstract no. PB0403). Unique
       Identifier : AIDSLINE ICA10/94369870
 AB    OBJECTIVE: We have previously described (9th International AIDS
       conference, 1993) an increased incidence of HIV EIA positive
       indeterminate Western Blot (IWB) in 17 out 520 hemodialysis patients
       (HDP). We now compare HDP with IWB which did not become positive WB
       during a three-year follow up and HDP without IWB to determine whether
       any differences may be found between the two groups. METHODS: Seventeen
       HDP with IWB (Pasteur), Group 1, were compared to 42 other HDP, Group 2,
       with respect to demographic data, blood groups, duration, blood
       transfusions and HBV serology. Statistical analysis was performed using
       the T-test and chi-square method. RESULTS: The average number of blood
       transfusions was significantly higher in Group 1 HDP, 10.7 versus 1.6 in
       the control group (p < 0.02). Seven of Group 1 had undergone rejection
       following a renal transplant in contrast to two of Group 2 HDP (p <
       0.002). Six of Group 1 in contrast to two of Group 2 HDP were Rh
       negative (p < 0.01). There were no significant differences with respect
       to sex, country of origin, duration of dialysis, and ABO blood group.
       DISCUSSION AND CONCLUSION: There was a higher incidence of blood
       transfusions and renal transplant rejection in HDP with IWB. This study
       supports the importance of transplantation antigens as factors in the
       development of IWB.
 DE    AIDS Serodiagnosis/*METHODS  *Blood Transfusion  *Blotting, Western
       Follow-Up Studies  Graft Rejection/IMMUNOLOGY  *Hemodialysis  Human  HIV
       Antibodies/*BLOOD  HIV Seropositivity/*DIAGNOSIS/IMMUNOLOGY  Kidney
       Transplantation/IMMUNOLOGY  Predictive Value of Tests  Risk Factors
       MEETING ABSTRACT

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