Document 2721
 DOCN  M94A2721
 TI    HIV-1 incidence in adults and risk factors for seroconversion in a rural
       population in Uganda: 3 years of follow-up.
 DT    9412
 AU    Kengeya-Kayondo J; Kamali A; Nunn AJ; Malamba S; Wagner HU; Mulder DW;
       Medical Research Council AIDS Programme, Entebbe, Uganda.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):24 (abstract no. 068C). Unique
       Identifier : AIDSLINE ICA10/94369854
 AB    OBJECTIVES: To determine over a three year period the HIV-1 incidence
       and to study risk factors associated with seroconversion in a rural
       population cohort. METHODS: A cohort of approximately 10,000 persons in
       a rural sub-county of S-W Uganda was enrolled in 1989-90 through
       sociodemographic and serological surveys which were repeated annually
       over a three year period. Serostatus was determined using two
       independent ELISA assays and western blotting when appropriate.
       Incidence rates were calculated per 1000 person years. Intervention
       efforts in the area include behaviour change messages and limited condom
       distribution. RESULTS: At the time of enrolment the overall prevalence
       of HIV-1 infection in the adult population was 8.2%. During three years
       of follow-up, the incidence of HIV-1 infection in adults (aged 13 yrs or
       more) was 6.2 (95% CI = 4.6 to 7.7). Although rates were highest in
       those aged 25-34 years (9.4), this was not significantly different from
       those aged 35 or more (6.6; p > 0.2); neither was the difference between
       males and females (6.5 and 5.9 respectively; p > 0.2). Annual incidence
       rates by calendar year declined from 7.5 in 1989/90 to 4.6 in 1993 (p >
       0.2). Non-Muslims had a higher risk than Muslims (8.2 vs 3.9 p = 0.07)
       as did non-Baganda compared to Baganda (9.4 vs 6.0). Persons who had
       moved to their present residence less than 10 years previously were
       twice as likely to seroconvert than those who had been at their
       residence for longer (11.0 and 4.8 respectively; p < 0.04). CONCLUSIONS:
       In this rural population with a considerable HIV prevalence, incidence
       rates appear to be declining with only modest intervention efforts and
       are similar for different age groups. Special AIDS prevention efforts
       are needed to reach recent immigrants and to communicate better with
       minority tribes.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  Adolescence  Adult
       Cohort Studies  Ethnic Groups  Female  Human  HIV
       Seropositivity/*EPIDEMIOLOGY  *HIV-1  Incidence  Male  Prevalence  Risk
       Factors  Rural Population  Uganda/EPIDEMIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).