Document 2763
 DOCN  M94A2763
 TI    Antigens and antibodies for HIV type 1 in serum, saliva and gingival
       fluid in patients with advanced disease.
 DT    9412
 AU    Ramos J; Arce AY; Santos SI; Morones MT; Mendoza J; School of Medicine,
       U.A.N.L., Monterrey, Nuevo Leon, Mexico.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):230 (abstract no. PB0348). Unique
       Identifier : AIDSLINE ICA10/94369812
 AB    OBJECTIVES: To determine the presence of antigens (Ags) and antibodies
       (Abs) for type 1 HIV in serum, saliva and gingival fluid in patients in
       stage 6 Walter Reed (WR) classification; and to describe the spectra of
       oral lesions. METHODS: 25 male patients who met the criteria of the WR6,
       attending the infectious disease Clinic, accepting to participate,
       underwent extensive evaluation and X rays. Saliva was obtained with a
       Pasteur pipette, gingival fluid was collected with filter and
       nitrocellulose paper. Blood was drawn in the same visit. Ags were
       determined by ELISA (Organon) and Abs by ELISA (Behring) a qualitative
       result was obtained in both tests. TABULAR DATA, SEE ABSTRACT VOLUME.
       DISCUSSION AND CONCLUSIONS: The presence of HIV Ags in the gingival
       fluid was found in 12% of these patients with advanced disease and 12%
       additional in saliva for a total of 24% in oral fluids. The Abs in
       saliva were present only in half of the patients, cautioning reliability
       of saliva as a diagnostic tool. Extensive periodontal damage is present
       in most of the individuals at this stage of HIV infection. Interestingly
       hyperpigmentosis was present in the majority of our patients contrary to
       reports in the literature which regarded it as a rare condition.
 DE    Adult  Comparative Study  Enzyme-Linked Immunosorbent Assay  Exudates
       and Transudates/*IMMUNOLOGY  False Negative Reactions
       Gingiva/*IMMUNOLOGY  Human  HIV Antibodies/*ANALYSIS/BLOOD  HIV
       Antigens/*ANALYSIS/BLOOD  HIV Infections/COMPLICATIONS/*IMMUNOLOGY
       HIV-1/*IMMUNOLOGY  Male  Periodontal Diseases/COMPLICATIONS
       Pigmentation Disorders/COMPLICATIONS  Saliva/*IMMUNOLOGY  Salivary
       Proteins/*ANALYSIS  Specimen Handling  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).